Cannabinoid type-1 (CB1) receptor antagonists were among the most promising drug targets in the last decade. They have been explored and found to be effective as therapeutic agents for obesity and related cardiometabolic problems, including e.g. dyslipidaemias, diabetes, and metabolic syndrome. However, the use of rimonabant, the first marketed CB1 receptor antagonist, has been suspended due to...

Abstract Background Rhizosphere microbiomes are fundamental for plant health, development, and productivity, but can be altered by the incidence of soil-borne pathogens. The dysbiosis (disturbance microbiome structure healthy plants) caused these pathogens, combined with recruitment beneficial microorganisms diseased plant, may cause shifts in rhizosphere during infection process. These likely ...

background despite several studies investigating the pathophysiologic effects of tourniquet usage in extremity surgeries, there are not enough data about these effects in adhesion release surgeries of burn patients. in the light of numerous metabolic changes of burn tissues, we tried to determine whether there are any significant differences in metabolic responses of burn tissues to tourniquet ...

Drugs that produce responses by interacting with adrenoceptors are referred to as adrenoceptor agonists or adrenergic agonists. Norepinephrine and isoproterenol are examples of such compounds. Agents that inhibit responses mediated by adrenoceptor activation are known as adrenoceptor antagonists, adrenergic antagonists, or adrenergic blocking agents. Prazosin and propranolol are examples of rec...

Volatile organic compounds (VOCs) are involved in microbial interspecies communication and the mode of action various antagonistic interactions. They important for balancing host-microbe interactions provide basis developing biological control strategies to plant pathogens. We studied between bacterial antagonist Serratia plymuthica HRO-C48 three fungal pathogens Rhizoctonia solani, Leptosphaer...

The visual design of antagonists—typically thought as “bad guys”—is crucial for game design. Antagonists are key to providing the backdrop a game's setting and motivating player's actions. representation antagonists is important because it affects player expectations about character's personality potential Particularly how players perceive an antagonist's morality. For example, antagonist appea...

In the canine femoral bed, we studied the involvement of vascular o2-adrenergic receptors in vasoconstriction by stimulating the sympathetic nerve during different degrees of activation of metabolic counter-regulation (constant pressure and constant flow perfusion). In chloraloseanesthetized, despinalized dogs under /3-blockade (2 mg/kg nadolol) and under a constant femoral perfusion pressure, ...

Quantitative structure-activity relationship (QSAR) models were employed for prediction the activity of P2X7 receptor antagonists. A data set consisted of 50 purine derivatives was utilized in the model construction where 40 and 10 of these compounds were in the training and test sets respectively. A suitable group of calculated molecular descriptors was selected by employing stepwise multiple ...

statement of the problem: various researchers have suggested the use of β2-adrenergic receptor antagonists in prevention or treatment of bone resorption. purpose: this study aimed to evaluate the effect of β2-adrenergic receptor antagonists on number of osteoclasts and osteoblasts involved in the healing of extraction socket of maxillary first molar in rats. materials and method: maxillary firs...