Thiazole is an important nucleus owing to its wide range of medical uses. It contains components that are anti-bacterial, anti-fungal, anti-malarial, anti-cancer, anti-allergic, anti-hypertensive, anti-inflammatory, and anti-psychotic, as well antioxidant, analgesic, antimicrobial. The thiazole scaffold has been detected in the more than eighteen FDA-accepted medicines addition countless resear...

abstract   the mutagenic and immunosuppressory effects of cyclophosphamide (cyp) are still the primary limitation to wider application for treating a variety of human malignancies. on the one hand, cyp treatment predisposes transplant recipients and cancer patients to risk of bacterial, fungal, and viral infections, in the other word the, lipopolysaccharide (lps), an endotoxin found in cell wal...

The antibacterial activity of pterostilbene in combination with gentamicin against six strains of Gram-positive and Gram-negative bacteria were investigated. The minimum inhibitory concentration and minimum bactericidal concentration of pterostilbene were determined using microdilution technique whereas the synergistic antibacterial activities of pterostilbene in combination with gentamicin wer...

Antibacterial activity of honey is due to the presence of methylglyoxal (MGO), H2O2, bee defensin as well as polyphenols. High MGO levels in manuka honey are the main source of antibacterial activity. Manuka honey has been reported to reduce the swarming and swimming motility of Pseudomonas aeruginosa due to de-flagellation. Due to the complexity of honey it is unknown if this effect is directl...

A system of surface treatment with an antibacterial agent and air recirculation through treated filters was set up in a 15-bedded surgical ward, using an adjacent 10-bedded ward as a control.Nasal, wound, and urinary cross-infection was studied in both wards for over one year.Total bacterial counts and counts of Staphylococcus pyogenes were made from settle plates and blanket sweep plates. Afte...

Growing resistance to antibacterial agents has increased the need for the development of new drugs to treat bacterial infections. Given increasing pressure on limited health budgets, it is important to study the cost-effectiveness of these drugs, as well as their safety and efficacy, to find out whether or not they provide value for money and should be reimbursed. In this article, we systematic...

Antibacterials are among of the most important medications used in health care. However, their efficacy is increasingly impeded by a tremendous and globally spread bacterial resistance phenomenon. This bacterial resistance is accelerated by inadequate application of antibacterial drugs in humans, the widespread veterinary use of antibacterials, and antibacterial occurrence in the environment an...