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BACKGROUND We have documented a high prevalence of Helicobacter pylori infection in patients with glaucoma. OBJECTIVE To evaluate the effect of H pylori eradication on the 2 most commonly used glaucoma parameters: intraocular pressure and visual field. METHODS A total of 41 patients with glaucoma and 30 age-matched anemic controls underwent upper gastrointestinal endoscopies and gastric muc...

In patients with diabetes mellitus (DM), chronic infections are frequent and severe due to the impairment of their immune status. However, data on the prevalence of Helicobacter pylori (H. pylori) infection in DM type II (DMT2) are scanty and contradictory. Aim of this study was to evaluate the prevalence of H. pylori infection in DMT2 patients in Northern region of India (Rajasthan state, more...

Background Until now, no study has been reported investigating the association between β-thalassemia minor and Helicobacter pylori (H. pylori) infection. This study was designed to compare H. pylori infection rate between β-thalassemia minor patients and healthy controls. Methods A number of 100 β-thalassemia minor patients (50 males, 50 females) and 100 gender-matched healthy controls were p...

BACKGROUND The epidemiology of Helicobacter pylori (H. pylori) infection in waste pickers had not been previously studied. This study aims to determine the association of H. pylori seropositivity and waste picking activity; and to determine socio-demographic, clinical, work, and behavioral characteristics associated with H. pylori seropositivity in waste pickers. METHODS Through a case-contro...

Approximately 50% of Helicobacter pylori isolates produce a cytotoxin in vitro that induces vacuolation of eukaryotic cells. To determine the in vivo relevance of this phenomenon, we sought to detect cytotoxin-neutralizing antibodies in sera from H. pylori-infected persons. As a group, sera from 29 H. pylori-infected patients neutralized the activity of the purified cytotoxin to a significantly...

Although many studies have shown that smoking is an established risk factor for gastric cancer, relatively few studies have investigated on which step smoking has effects in Helicobacter pylori (H. pylori) related gastric carcinogenesis. In this study we investigated the association of smoking with risk of three steps leading to gastric cancer: H. pylori infection, gastric atrophy, and gastric ...

Recently, a potential link between infectious agents and athero-sclerosis has been suggested. H. pylori strains bearing the cytotoxin associated gene A (Cag-A) provoked a heightened inflammatory response in vivo and showed stronger relation to gastric complication of this infection. The association between Cag-A positive strain and vascular diseases producing conflicting results. So, the presen...

Comprehensive Summary Helicobacter pylori ( H. ) infection is a threat to human health. The lipopolysaccharide (LPS) O‐antigen holds promise for developing vaccines. It meaningful explore the immunological activity of oligosaccharides with different lengths and frameshifts antigen development. Herein, glycan library O2 containing eight fragments constructed. After screening anti‐ LPS sera patie...