'Transcalciferin' (the serum transport protein for cholecalciferol and related substances) of two New World monkeys, Cebus apella and Cebus albifrons, was found to be immunologically identical with the transcalciferin of other monkeys and partially with that ofman. In contrast with the a-globulin mobility of the transcalciferin of other primates, the transcalciferin of cebus monkey has the elec...

Preventing xenograft rejection is one of the greatest challenges of transplantation medicine. Here, we describe a reproducible, long-term survival of cardiac xenografts from alpha 1-3 galactosyltransferase gene knockout pigs, which express human complement regulatory protein CD46 and human thrombomodulin (GTKO.hCD46.hTBM), that were transplanted into baboons. Our immunomodulatory drug regimen i...

Objectives: To explore the expression of maternal serum IgG anti-A (B) and neonatal direct anti globulin, free antibody and Red Blood Cell (RBC) antibody on the occurrence and development of ABO Haemolytic Disease of the New-born (ABO-HDN) and provide a valuable reference for the early diagnosis of the disease. Methods: we selected 546 cases of jaundice and hyperbilirubinemia neonates in our ho...

Antihemophilic factor (AHF, Factor VIII) antigen has been demonstrated in cultured human endothelial cells by immunofluorescence studies using monospecific rabbit antibody to human AHF. Control studies with cultured human smooth muscle cells and human fibroblasts were negative. By radioimmunoassay it was demonstrated that cultured human endothelial cells contain AHF antigen which is released in...

We reported here on a case of limited cutaneous systemic sclerosis (lcSSc) with aplastic anemia treated by anti-thymocyte globulin and cyclosporin A. The use of this therapy resulted not only in marrow recovery but also in resolution of the skin sclerosis. A 68 year-old woman was diagnosed as lcSSc accompanied by Hashimoto's thyroiditis and primary biliary cirrhosis. Treatment by D-penicillamin...

The means by which interaction of antigen and antibody may lead to disease is not well understood. Arthus (1) observed that repeated subcutaneous injections of horse serum in rabbits elicited progressively severe local inflammatory reaction. From clinical observations on serum disease in man yon Pirquet (2) suggested "that a disease might be due indirectly to an antibody" and he coined the term...

Antilymphocyte globulin (ALG) was given every other day for 5 doses with platelet transfusions immediately following ALG administration in 6 patients with aplastic anaemia. Four patients responded and 3 durable remissions were achieved. One patient relapsed and further treatment with anti-thymocyte globulin and cyclosporin also failed. One patient died of Flavobacterium septicaemia 6 days after...

The upstream activation site (UAS) of the yeast phosphoglycerate kinase gene (PGK) has been localised by deletion analysis (1). Here we show that the UASPGK contains two functionally distinct domains. These two domains, designated activator (A) and modulator (M), appear to be located within bases -460 to -402 and -531 to -461, respectively, relative to the initiating ATG; although it is possibl...

The International Symposium on Auto­ phagy (ISA) is an important meeting with a long history devoted solely to the topic of autophagy. Yoshimori Ohsumi (Tokyo Institute of Technology, Japan), who identified a series of autophagy­related genes (ATG genes) in yeast [1], proposed and organized the first ISA in Okazaki, Japan, in 1997. Over the years, the ISA sym­ posia have witnessed the explosive...

Large doses of antihuman lymphoblast globulin (AHLG) were used prophylactically in three recipients of renal allografts from living related donors. These recipients received 1, 500 mg/day of AHLG for 14 days begining on the second day before transplantation in addition to the standard immunosuppression. Serum AHLG levels, serum anti-AHLG antibodies and T cell subsets were checked serially. The ...