anti thymocyte globulin

Journal: :Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1997

C Prin Mathieu E Renoult A Kennel De March M C Béné M Kessler G C Faure

BACKGROUND The therapeutic efficacy of horse antilymphocyte globulins (ALG) or of rabbit antithymocyte globulins (ATG), used for both the prevention and treatment of allograft rejection has been well documented. However, clinical use of these heterologous antibodies can result in the production of antibodies against horse or rabbit proteins and in the development of serum sickness via circulati...

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Treatment of acute graft versus host disease with low dose-alternate day anti-thymocyte globulin.

Journal: :Haematologica 2002

Francesco Graziani Maria Teresa Van Lint Alida Dominietto Anna Maria Raiola Carmela Di Grazia Teresa Lamparelli Francesca Gualandi Stefania Bregante Merilù Fiorone Barbara Bruno Andrea Bacigalupo

BACKGROUND AND OBJECTIVES The efficacy of antithymocyte globulin (ATG) in the treatment of graft-versus-host disease (GvHD) is controversial. In the present study we report on the use of low dose ATG (thymoglobuline, Sangstat) and steroids in 28 patients with moderate to severe acute GvHD. DESIGN AND METHODS Fifteen patients received ATG as first-line treatment within 14 days of the diagnosis...

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