From centuries human has been afflicted by urinary calculi (Urolithiasis). These calculi are formed from crystal aggregation and retention in the urinary tract. The incidence and prevalence of urolithiasis may be related to various factors including age, sex, ethnicity, diet, fluid intake, genetic predisposition, climatic conditions, and urinary tract infections. Study of chemical composition a...

Two commercial databases (Pharmaprojects and Adis Insight R&D) were queried for antibacterial agents in clinical development. Particular attention was given to antibacterial agents for systemic administration. For each agent, reviewers were requested to indicate whether its spectrum of activity covered a set of selected multidrug-resistant bacteria, and whether it had a new mechanism of action ...

background trachyspermum ammi or carum copticum, commonly known as ajowan or ajwain is a plant used as a spice. thymol, the major phenolic compound present in ajowan is known as a strong germicide and anti-spasmodic. it is also used for cleaning the wounds and treating skin infections. objectives here, we aimed to study the inhibitory effects of ajowan essential oil on microorganisms like esche...

This study investigates the antibacterial mechanism of action of electrospun chitosan-based nanofibers (CNFs), against Escherichia coli, Salmonella enterica serovar Typhimurium, Staphylococcus aureus and Listeria innocua, bacteria frequently involved in food contamination and spoilage. CNFs were prepared by electrospinning of chitosan and poly(ethylene oxide) (PEO) blends. The in vitro antibact...

γ-AApeptides are a new class of antibacterial peptidomimetics that are not prone to antibiotic resistance and are highly resistant to protease degradation. It is not clear how γ-AApeptides interact with bacterial membranes and alter lipid assembly, but such information is essential to understanding their antimicrobial activities and guiding future design of more potent and specific antimicrobia...

Daptomycin, a new lipopeptide antibiotic, is highly bactericidal against the majority of Gram-positive human pathogens, including methicillin-resistant (MRSA) and vancomycin-resistant enterococci. Its mechanism of action is unique resulting in the destruction of the membrane potential without lysing the cell wall. The mechanism of action of daptomycin, its antibacterial spectrum, the developmen...

Nikkomycins and polyoxins are antifungal peptidylnucleoside antibiotics active against human and plant pathogens. Here we report that during peptidylnucleoside biosynthesis in Streptomyces cacaoi and S. tendae, the C5' extension of the nucleoside essential for downstream structural diversification is catalyzed by a conserved radical S-adenosyl-L-methionine (SAM) enzyme, PolH or NikJ. This is di...

Background: Xylocarpus granatum has been used traditionally by coastal communities to treat various diseases. It is known that this plant contains secondary metabolites with pharmacological activities, including as an antibacterial. Objective: This review article aims provide information regarding the potential antibacterial activity of banang-banang plants and summarize content compounds have ...

A mixture of hydrogen peroxide and ascorbic acid has been found to generate an antibacterial mechanism which is active against gram-negative bacteria. It results in bacterial death and renders the organism sensitive to lysis by lysozyme. Under the conditions used, horseradish peroxidase did not augment the antibacterial effect. It is suggested that the effector mechanism involves the generation...

2 RÉSUMÉ Flo, un peptide antibactérien isolé de l'arbre tropical Moringa oleifera: Une base pour de nouvelles substances antibactériennes Les peptides antimicrobiens sont essentiels à la survie d'organismes multicellulaires. Ils servent à lutter contre des microbes pathogènes et à contrôler les communautés commensales inoffensives. Jusqu'à aujourd'hui ces peptides n'ont pas permis aux microbes ...