BACKGROUND Most clinical isolates that exhibit a multi-drug resistant phenotype owe that resistance to over-expressed efflux pumps. Compounds that are efflux pump inhibitors (EPIs) reduce or reverse resistance to antibiotics to which the bacterial strain is initially resistant. We have evaluated non-antibiotics to reduce resistance of commonly encountered bacterial pathogens to antibiotics. M...

The isolation of paulomycins A and B from fermentations of Streptomyces paulus has been reported earlier [J. Antibiotics 35: 285-294, 1982]. Further work on the antibiotics produced by S. paulus revealed the production of two paulomycin-related compounds, antibiotics 273a1 and 273a2 which were isolated by procedures involving extractions and chromatography over buffered silica gel. Antibiotic 2...

Growing antibiotic resistance is a global phenomenon in both developed and developing countries. Methicillin-resistant Staphylococcus aureus (MRSA) alone infects more than 94 000 people and kills nearly 19,000 in the US every year, more deaths than are caused by HIV/AIDS, Parkinson’s disease, emphysema, and homicide combined(1). Penicillin-resistant streptococcal pneumonia and vancomycin resist...

objective(s) developing and validating a simple, efficient, reproducible and economic reversed phase high performance liquid chromatographic (rp-hplc) method for the quantitative determination of pefloxacin in bulk material, tablets and in human plasma. materials and methods a shim-pack clc-ods column and a mobile phase constituting acetonitrile: 0.025 m phosphoric acid solution (13:87 v/v, ph ...

this laboratory study simultaneously was conducted to evaluate the resistance to heavy metals, silver, cadmium and a number of commonly used antibiotics. sampling was done in 2014 of the two silver workshops in isfahan, and the inlet of phase 2 of shahin shahr wastewater treatment plant, isfahan. to isolate resistant bacteria to metal silver and cadmium and review multiple resistance to other m...

granulomatous mastitis (gm) is a rare breast disease with unknown etiology. clinical management strategies for gm include surgery, antibiotics, and steroid treatments. as patients with gm often respond to steroids, gm is thought to be an autoimmune disease. here we describe a case of trauma?induced gm that presented as autoimmune disease but was successfully treated by surgery without steroids....