BACKGROUND The purpose of this study was to examine the association between use of inhaled anticholinergics and all-cause mortality among elderly individuals with chronic obstructive pulmonary disease (COPD), after controlling for demographic, socioeconomic, health, functional status, smoking, and obesity. METHODS We used a retrospective longitudinal panel data design. Data were extracted for...

forty-five patients with chronic obstructive pulmonary disease were studied to compare the acute effects of ipratropium bromide (60 µg), salbutamol (300 µg) and placebo (3 puffs) on the forced expiratory volume in 1 sec (fev 1) and forced vital capacity (pvc). ipratropium bromide produced a significantly greater improvement than salbutamol in both fev1 and fvc at 15,60 and 180 minutes after dru...

PURPOSE The objective of this study was to evaluate the influence of propiverine-HCl (P4) and propiverine-N-oxide (P4NO), one of the major metabolites of P4, on bladder contraction in a standardized in vivo model. Additionally, salivary flow measurements enabled the evaluation of hyposalivation, one of the most predominant anticholinergic side effects. MATERIALS AND METHODS Ten male mini pigs...

In the present review, the main objective was to report the incidence and causes of herbal medicines induced anticholinergic poisoning in Hong Kong during 1989-2012 and to emphasize the importance of pharmacovigilance, investigations and preventive measures. Relevant papers, official figures and unpublished data were obtained from Medline search, the Department of Health and the Drug and Poison...

recent developments and anesthetic implications. Anesthesiology 1996; 84: 173–89 2 Lydic R, Baghdoyan HA. Cholinergic contributions to the control of consciousness, anesthesia. In: Yaksh TL, Lynch C III, Zapole WM, Maze M, Biebuyck JF, Saidman LJ, eds. Biologic Foundations. Philadelphia: Lippincott-Raven, 1997; 433–50 3 Meuret P, Backman SB, Bonhomme V, Plourde G, Fiset P. Physostigmine reverse...

INTRODUCTION To evaluate the efficacy and safety of onabotulinumtoxinA for the treatment of neurogenic detrusor overactivity (NDO) in subpopulations of etiology (multiple sclerosis [MS] or spinal cord injury [SCI]) and concomitant anticholinergics (use/non-use). METHODS Data were pooled from two double-blind, placebo-controlled, pivotal, phase 3 studies including a total of 691 patients with ...

BACKGROUND Evidence is lacking about outcomes associated with the cumulative use of anticholinergic and sedative drugs in people with Alzheimer's disease (AD). This retrospective cohort study investigated the relationship between cumulative exposure to anticholinergic and sedative drugs and hospitalization and mortality in people with and without AD in Finland. METHODS Community-dwelling peop...

BACKGROUND Review of recent journal articles and various relevant current textbooks provides strong evidence to show that anticholinergic burden is a material issue in frail and at-risk patients. This study assesses the anticholinergic burden in a group of patients in residential care facilities and then applies a theoretical intervention model. It is based on a scoring system known as the Anti...