In the present work, some new 5-[2(3)-dialkylamino alkoxy] Indole 2, 3-diones and 5-Hydroxyindole 3semicarbazone 2-ones were prepared from 5-hydroxy isatin. The structures of the products were characterized by IR, NMR, MASS Spectral studies. All the compounds were examined for anticonvulsant activity by maximal electroshock seizure (MES) and pentylenetetrazole (PTZ) induced convulsion method. T...

The search for antiepileptic compounds with more selective activity and lower toxicity remains an area of intensive investigation in medicinal chemistry. Hydrazone derivatives are significant because of their versatile biological actions. Hydrazone derivatives play an important role in development of various research activities such as anticonvulsant, vasodilator, antimycobacterial, antiviral, ...

Cannabidiol (CBD) exhibits anticonvulsant activity in experimental animals and in man. As part of a structureactivity study, analogs were prepared wherein the terpene unit, the aryl unit, and/or the side chain were modified. Thus, several pinenyl and carenyl derivatives, aryl ethers and acetates, and a variety of 1",1"-dialkylhexyl and 1",1"dialkylheptyl analogs were synthesized. The compounds ...

BACKGROUND AND PURPOSE OF THE STUDY Fabaceae is the third largest family of flowering plants. Lack of essential oils in the plants of this family can be an advantage in search for safe and effective medicines. In this study the anticonvulsant effect of the leaves of Albizzia julibrissin, Acacia juliflora, Acacia nubica and aerial parts of Astragalus obtusifolius was evaluated in pentylenetetraz...

BACKGROUND Cytisine (CYT), the most commonly used drug for smoking cessation in Poland, was experimentally found to induce convulsions. There is a lack of studies on the influence of CYT on the anticonvulsant activity of antiepileptic drugs (AEDs). METHODS The effects of CYT on the anticonvulsant activity of six AEDs were examined in maximal electroshock (MES)-induced seizures in mice. RESU...