BACKGROUND Increase in resistance of Candida species, to routinely used antifungal agents has necessitated the quest for new drugs. Few studies have revealed that cow's urine can suppress the growth of pathogenic fungi. However there is no published report on antifungal effects of cow's urine on clinical Candida isolates. OBJECTIVE The present study aims at exploring the antifungal potential ...

To investigate the influence of N- or C-terminal regions of pleurocidin (Ple) peptide on the antifungal activity, four analogues partially truncated in the N- or C-terminal regions were designed and synthesized. Circular dichroism (CD) spectroscopy demonstrated that all the analogues maintained an alpha-helical structure. The antifungal susceptibility testing also showed that the analogues exhi...

Increasing evidence of fungicide-resistant toxinogenic and pathogenic fungal species is obvious. Looking for new possibilities of antifungal treatment or sources of antifungal substances is a major problem. Some medicinal plants exert strong antifungal properties and could be conveniently used as a promising alternative source for presently problematic antifungal treatment in many areas with re...

Finding effective drugs to treat fungal infections has important clinical significance based on high mortality rates, especially in an immunodeficient population. Traditional antifungal drugs with single targets have been reported to cause serious side effects and drug resistance. Nowadays, however, drug combinations, particularly with respect to synergistic interaction, have attracted the atte...

This study investigated the antifungal activity and potential antifungal mechanism(s) of isoliquiritin against P. litchi Chen, one of the main litchi pathogens. The antifungal activity of isoliquiritin against P. litchi Chen had been proven in a dose-dependent manner through in vitro (mycelial growth and sporangia germination) and in vivo (detached leaf) tests. Results revealed that isoliquirit...

There are many reports about antifungal and antimicrobial effects of Myrtle extract. In respect to resistance of fungal strains to current antifungal drugs such as imidazole derivatives, a comparative study was carried out to Investigate the antifungal effect of Myrtle extract versus clotrimazole on candida albicans, the most common cause of vaginal candidiasis . The vaginal discharge of 500 pa...

Background and Aim: There are some rich sources of antifungals in medicinal herbs. They have general acceptance due to their low cost and insignificant side effects. The efficacy of Peganum harmala (P. harmala) extract against Candida species was investigated in this study.    Materials and Methods: In this in vitro study, we used the maceration technique to obtain P. harmala aqueous and al...

indiscriminate and excessive uses of antibiotics may be lead promote the emergence of antibiotic-resistant microorganisms and side effects in patients. therefore the researchers recently have focused on the use of natural resources, especially medicinal plants. ruta graveolens is a kind of medical plants which contains antifungal and antibacterial components and use in traditional medicine in i...

Dodecyl protocatechuate (dodecyl) is a derivative of protocatechuic acid (3,4-dihydroxybenzoic acid) that possesses anti-oxidant and antifungal properties. Nanostructured lipid systems (NLS) can potentiate the action of many antifungal agents, reducing the required dose and side effects by improving their activity. This work aimed to evaluate dodecyl protocatechuate loaded into a NLS (NLS+dodec...

BACKGROUND Frequent opportunist fungal infections and the resistance to available antifungal drugs promoted the development of new alternatives for treatment, like antifungal drug combinations. AIMS This work aimed to detect the antifungal synergism between statins and azoles by means of an agar-well diffusion bioassay with Saccharomyces cerevisiae ATCC 32051 and Candida utilis Pr(1-2) as tes...