Background The purpose of this study was to identify chronic urticaria (CU) etiologies and treatment modalities in Ecuador. We propose that the sample distribution fits the expected one, and that there is an association between the etiology and its treatment. Methods We performed a retrospective study involving 112 patients diagnosed with CU using a Checklist for a complete chronic urticaria ...

BACKGROUND Treatment with second-generation antihistamines is recommended in patients with chronic spontaneous urticaria (CSU). Some patients remain unresponsive even after up-dosing up to fourfold. Many third line treatment options have limited availability and/or give rise to significant side effects. We investigated effectiveness and safety of antihistamine treatment with dosages up to fourf...

The pharmacodynamics of drug-candidates is often optimized by metrics that describe target binding (Kd or Ki value) or target modulation (IC50). However, these metrics are determined at equilibrium conditions, and consequently information regarding the onset and offset of target engagement and modulation is lost. Drug-target residence time is a measure for the lifetime of the drug-target comple...

OBJECTIVE To evaluate how well the medications currently approved in the United States for allergic rhinitis (AR) treat nasal symptoms when examined according to Food and Drug Administration-indicated uses and dosages. DATA SOURCES MEDLINE (1966 onward), EMBASE (1974 onward), and the Cochrane Library (2007) were systematically searched according to the following criteria defined at a roundtab...

OBJECTIVE To determine whether intranasal corticosteroids are superior to oral H1 receptor antagonists (antihistamines) in the treatment of allergic rhinitis. DESIGN Meta-analysis of randomised controlled trials comparing intranasal corticosteroids with oral antihistamines. SETTING Randomised controlled trials conducted worldwide and published between 1966 and 1997. SUBJECTS 2267 subjects...

It's a great idea that you're looking into whether certain substances may have the potential for problematic or undesirable results! To answer your question ? it?s best to avoid mixing alcohol and antihistamines, as they both depress the central nervous system (CNS) [2], thereby impairing your ability to coordinate physical motor movements and remain awake and conscious. Additionally, alcohol d...

cyanosis with great dyspnea is the outstanding clinical feature . . . A yellow serous fluid fills the air passages in such quantities that it may drip from the mouth of the living patient when the stretcher is tilted head downwards. Death in this stage may occur at any time from the first to the fourth or fifth day. . . . Secondary infection of the Imniclniil.il passages and lungs may develop, ...

It's a great idea that you're looking into whether certain substances may have the potential for problematic or undesirable results! To answer your question ? it?s best to avoid mixing alcohol and antihistamines, as they both depress the central nervous system (CNS) [2], thereby impairing your ability to coordinate physical motor movements and remain awake and conscious. Additionally, alcohol d...