Synthesis of Silver Nanoparticles using Methanol Extract Bunium Persicum and the Evaluation its Cytotoxic, Antileishmanial, Antimicrobial Activities

Leishmaniasis is a neglected tropical disease. According to the World Health Organization, there are approximately 1.5-two million new cases of cutaneous leishmaniasis each year worldwide. Chemotherapy against leishmaniasis is based on pentavalent antimonials, which were developed more than a century ago. The goals of this study were to investigate the antileishmanial activity of diterpene acid...

EGFR is a key player in the signalling cascades of various kinds cancers and tyrosine kinase inhibitors block signalling. Natural products have long been used as candidates for therapy management cancer. Violacein, bacterial pigment, has known its numerous biological applications such antimicrobial, antileishmanial, antiviral, well antitumoral. Computational studies concluded that it may activi...

In this study, antibacterial, antifungal, antimycobacterial, cytotoxic, antitumor, cardiovascular, antifeedant, insecticidal, antileishmanial and some other single activities of diterpenoids and norditerpenoids isolated from Turkish Lamiaceae plants, are reviewed. The diterpenoids were isolated from species of Salvia, Sideritis, and Ballota species growing in Anatolia. Fifty abietanes, ten kaur...

Angelica dahurica (Fisch. Ex Hoffm) is an important traditional Chinese herb which is widely used in curing acne, ulcers, carbuncles, rheumatism, headaches and toothaches. A systematic antifungal bioassayguided fractionation of the ethyl acetate extract from A. dahurica led to the isolation of six coumarins, namely, suberosin, bergapten, alloimperatorin, xanthotoxol, 5-methoxy-8-hydroxypsoralen...

Bioassay-guided fractionation of a chloroform extract of Valeriana wallichii (V. wallichii) rhizomes lead to the isolation and identification of caffeic acid bornyl ester (1) as the active component against Leishmania major (L. major) promastigotes (IC50 = 48.8 µM). To investigate the structure-activity relationship (SAR), a library of compounds based on 1 was synthesized and tested in vitro ag...