Background: Reprogramming of cellular metabolism is one the hallmarks cancer (Hanahan, 2022), thus representing an important therapeutic target. 3-bromopyruvate (3BP or KAT/3BP) a small, highly reactive molecule formed by bromination pyruvate (Ko et al, 2012). The very high similarity its structure with pyruvic acid and lactic basis mechanism action as anti-cancer agent. Indeed, 3BP enters cell...

The methotrexate (MTX) is an antimetabolite, whose dosages vary according to indication. It used in the treatment of tumoral pathologies, as acute lymphoblastic leukaemias and, rheumatology, rheumatoid polyarthritis (RP) and other chronic inflammatory rheumatisms belongs group antifolates: it inhibits purine pyrimidine synthesis, which accounts for its efficacy therapy cancer well some toxiciti...

the major objective in endodontic therapy is to disinfect the entire root canal system. this requires that the pulpal content be eliminated as sources of infection. this goal may be accomplished by mechanical instrumentation and chemical irrigation, in conjunction with medication of the root canal between treatment sessions. microorganisms and their by-products are considered to be the major ca...

Methotrexate (MTX) is an antimetabolite which interferes with DNA synthesis, and it is used for the treatment of moderate to severe psoriasis, atopic dermatitis and a wide variety of cutaneous diseases. Although many adverse effects of MTX, including cutaneous ulcerations, have been documented, multifocal mucosal ulceration mimicking Behçet's disease has not been reported. In our case, a 63-yea...

Pseudomonas syringae is a phytopathogenic bacterium present in a wide variety of host plants where it causes diseases with economic impact. The symptoms produced by Pseudomonas syringae include chlorosis and necrosis of plant tissues, which are caused, in part, by antimetabolite toxins. This category of toxins, which includes tabtoxin, phaseolotoxin and mangotoxin, is produced by different path...

BACKGROUND AND AIM The immunosuppressive properties of 6-mercaptopurine and its parent compound azathioprine are mediated by their intracellular metabolism into active 6-thioguanine (6-TG) metabolites. Measurement of erythrocyte 6-TG metabolite levels has been proposed as a useful clinical tool for assessing treatment efficacy in patients with inflammatory bowel disease (IBD). AIM The purpose...

Paclitaxel and carboplatin is widely used in the treatment of patients with advanced non-small cell lung cancer (NSCLC); however, median survival remains < 1 year. One strategy to improve survival is to add a third active drug with a differing mechanism of action. Gemcitabine is a novel antimetabolite with considerable activity in NSCLC. The primary objective of this Phase I/II study was to det...

Daily treatment of mice with 0.8 mg methotrexate/kg/day for 14 days led to a transient splenic hyperplasia and increased spleen dihydrofolate reducÃ-ase activity after cessation of treatment. These effects were prevented by the simultaneous administration of 5-formyltetrahydrofolate. A similar increase in spleen size and dihydrofolate reducÃ-aseactivity occurred after treatment with 5-fluorodeo...

AZATHIOPRINE is an antimetabolite widely used to suppress the immune system in recipients of organ transplants, as well as in patients with primary autoimmune disorders. Over the past 30 yr, it has proved to be an effective agent. However, multiple side effects have been reported, ranging in severity from fever and rash to cardiovascular collapse. We report an acute idiosyncratic reaction to az...