objective(s):isoprenoid biosynthesis is a key metabolic pathway to produce a wide variety of biomolecules such as cholesterol and carotenoids, which target cell membranes. on the other hand, it has been reported that statins known as inhibitors of isoprenoid biosynthesis and cholesterol lowering agents, may have a direct antimicrobial effect on the some bacteria. the exact action of statins in ...

Radix aucklandiae from Yunnan Province in China is a significant medicinal plant. In the present study, the essential oil composition from Radix aucklandiae roots was investigated by gas chromatography-mass spectrometry (GC-MS). A total of 23 compounds representing 57.95% of the essential oil were tentatively identified. The main constituents were eremanthin (12.74%), d-Guaiene (6.26%), ζ-Himac...

This paper focuses on the significant properties of hydrogels prepared with polymeric biomaterials: solely biopolymers (gelatin (G) and sodium alginate (SA) as base polymer) or in combination with synthetic and bio polymers (polyvinylpyrrolidone (PVP) and carboxymethylcellulose (CMC)) for biomedical application. Four kinds of hydrogels: G/SA, G/SA/SB (without and with seabuckthron oil (SB)) and...

conventional transdermal drug delivery systems (tdds) have been designed for drug delivery through the skin. these systems use the permeability property of stratum corneum, the outermost surface layer of the skin. applying polymeric micro and nanofibers in drug delivery has recently attracted great attention and the electrospinning technique is the preferred method for polymeric micro-nanofiber...

Background: Over the years chlorhexidine has been used in the dental practice as an excellent antiplaque agent. Chlorhexidine not only exhibits special property of substantivity, it also possesses a broad antimicrobial spectrum which makes its use in wide variety of oral disorders. Virtually all disciplines of dentistry make use of this material in different formulations like mouth wash, gel, s...

This study was carried out to characterize antimicrobial, antioxidant and anticancer activities of Michelia champaca seed and flower extracts. The main objective of the present study was to reveal the medicinal values of M. champaca seed and flower for human uses. Antimicrobial property of M. champaca seed and flower extracts were revealed by using two fold microdilution method whereas antioxid...

As part of an effort to develop new, low molecular mass peptide antibiotics, we searched for the shortest bioactive analogue of gaegurin 5 (GGN5), a 24-residue antimicrobial peptide. Thirty-one kinds of GGN5 analogues were synthesized, and their biological activities were analyzed against diverse microorganisms and human erythrocytes. The structural properties of the peptides in various solutio...

Expression of the antimicrobial peptide hCAP18/LL-37 is associated to malignancy in various cancer forms, stimulating cell migration and metastasis. We report that LL-37 induces migration of three cancer cell lines by activating the TRPV2 calcium-permeable channel and recruiting it to pseudopodia through activation of the PI3K/AKT pathway. Ca2+ entry through TRPV2 cooperated with a K+ efflux th...

Objective - to evaluate both in-vivo and in-vitro antibacterial property of Aloe vera.L fresh gel. Design - experimental study. Animals - five adult male mixed breed dogs aged 2-4 years. Procedures - for in-vivo experiment, under general anesthesia and sterile condition 8 symmetrical full-thickness wounds measured 2 cm×2 cm were surgically created on the back of each dogs o...

Xylooligosaccharides derived from Xylan, significant component of hemicellulose in lignocellulosic plant biomass, are essential raw materials used the food, pharmaceutical and agricultural industries. They find application these industries due to their unique physicochemical properties such as pH stability, growth regulatory ability, anti-allergic property. In addition, they have been shown exh...