Natural products have a wide range of diversity multidimensional chemical structures which play vital role show the important nature as golden source for achieving herbal drug discovery. Literature survey was accomplished using multiple databases including PubMed, Science Direct, ISI web knowledge and Google Scholar. Epigallocatechin-3-gallate is most abundant tea polyphenol, followed by other ...

The use of herbal complementary and alternative medicines is growing among Portuguese cancer patients, contributing to a higher risk for unwanted interactions, especially due to the narrow therapeutic index of most oncolytic drugs. A literature review was carried out in order to determine which medicinal plants are most commonly used by cancer patients, in Europe and USA, and their risk of inte...

peperomia pellucida leaf extract was characterized for its anticancer, antimicrobial, antioxidant activities, and chemical compositions. anticancer activity of p. pellucida leaf extract was determined through colorimetric mtt (tetrazolium) assay against human breast adenocarcinoma (mcf-7) cell line and the antimicrobial property of the plant extract was revealed by using two-fold broth micro-di...

Cationic polymeric nanoparticles have great potential for developing drug delivery systemswith limited side effects for tumor medication. The goal of this research is investigation ofcationic dextran-spermine polymer (DS) efficacy for improvement of hydrophilic drug deliveryto negatively charged cancerous cells. Capecitabine (as a hydrophilic antineoplastic drug) wasloaded into the magnetic dex...

Endothelial cell migration is a critical event during angiogenesis, and inhibitors of cell motility can affect the angiogenic process. Paclitaxel (Taxol(R)), a microtubule-stabilizing antineoplastic cytotoxic drug, inhibits motility and invasiveness of several cell types. The aim of this study was to investigate the effect of paclitaxel on endothelial cell functions and on angiogenesis. In vivo...

Background. L-asparaginase is effective in treating canine and feline lymphoma, however chemotherapy poses a significant financial cost to veterinary clients, limiting therapy for many pets. Single dose vials result in significant drug wastage, and drug shortages limit consistent availability for pets. Hypothesis. E. coli-derived asparaginase retains enzymatic and antineoplastic activity in can...

BACKGROUND The antimalarial drug Pyrimethamine has been suggested to exert an antitumor activity by inducing apoptotic cell death in cancer cells, including metastatic melanoma cells. However, the dose of Pyrimethamine to be considered as an anticancer agent appears to be significantly higher than the maximum dose used as an antiprotozoal drug. METHODS Hence, a series of Pyrimethamine analogs...

cladribine acts as an antineoplastic, immunosuppressive and anti-inflammatory agent. the aim of this study was to examine the possible impact of this drug on the epidermis of wistar rats. the control group received standard feed and water. the experimental group i was treated with cladribine in a schema corresponding to the treatment of multiple sclerosis in humans. the material for microscopic...

Antineoplastic agents may be very effective in the first round of combination chemotherapy; however, upon subsequent treatment, many tumours display resistance. In many instances , drug resistance is observed to multiple agents which differ in structure as well as in their mechanism of action. Development of such multidrug resistance (MDR) is a major obstacle in the treatment of a variety of ma...