Down syndrome or trisomy 21 is the single most common genetic cause of mental retardation. It has been postulated that there is oxidative stress in Down syndrome due to over expression of superoxide dismutase 1 (SOD -1) , an antioxidant enzyme which is coded on chromosome 21(21q22.1). The present study included 31 clinically diagnosed children with Down syndrome. The diagnosis of trisomy 21 was...

Objective: The paraoxonase 1 (PON-1) enzyme is an important antioxidant. balance between oxidative stress and antioxidant defense mechanisms disturbed during asthma attacks. activity of the PON-1 related to gene polymorphism. This study aimed evaluate Q192R polymorphism in asthmatic children. Material methods: During 2013-2014 period, we performed a prospective with 34 (study group) healthy (co...

Okara (tofu dregs) is a soybean waste product from the tofu and soymilk processing industry. To create useful product, remaining protein content in okara must be used. The goal of this study was to determine enzyme-substrate (E/S) ratio capable producing highest antioxidant activity hydrolysate, as well amino acid composition such hydrolysate (especially potential antioxidants). produce concent...

Cadmium affects human health through occupational and environmental exposure. In this report, we present the response of mitochondrial and cytoplasmic antioxidant enzymes of CRL-1439 cells exposed to different concentrations (0-150 microM) of CdCl2 for 24 h at 37 degrees C. Exposure of liver cells to 50 microM CdCl2 increased mitochondrial catalase and glutathione reductase (GR) activities more...

background: in recent years, plants natural products have gained considerable attention as natural preservers for use in different industries. due to their free radical scavenging activities, phenolic compounds can prevent a wide range of diseases such as cancers and cardiovascular and neurodegenerative diseases. for a long time, different ferulago species have been in use as medicinal plants w...

the in vitro antioxidant and antimicrobial activities of the essential oil and methanolic extract of achillea sieheana staf. (asteraceae) were investigated in this study. the chemical composition of the essential oil isolated by hydro-distillation from the aerial parts of a. sieheana was analyzed by gc–ms. camphor (43.36%), artemisia ketone (25.95%), 1.8-cineole (6.29%) and camphene (4.77%) wer...

Exercise in cold environments can cause significant metabolic regulation and antioxidant behavior. For discussing enzymatic responses towards cold adaptation, we investigated enzyme activities of adenylate cyclase (AC) and phosphodiesterase (PDE) in liver, skeletal muscle, and brown adipose tissue (BAT), as well as Na(+)·K(+) ATPase and Na(+)/K(+) ratio in blood. Malondialdehyde (MDA) and super...

Our previous studies have shown that exercise caused changes in the tissue activities of the antioxidant enzymes glutathione peroxidase, superoxide dismutase, and catalase in spontaneously hypertensive (SH) and Wistar-Kyoto (WKY) rats. To determine whether the changes observed were due to changes in mRNA levels of the enzymes, levels of tissue mRNA were determined by quantitative RNase protecti...

objective(s): mindium laevigatum is an endemic plant of iran and turkey and is widely used as blood purifier, antiasthma and antidyspnea in traditional medicine. chemical composition of volatile materials of the plant and its antioxidant, antimicrobial and cytotoxic activities were reported in this study. materials and methods: simultaneous distillation-extraction (sde) and gc-mass-fid analysis...

Declines in oxidative and thermal stress tolerance are well documented in aging systems. It is thought that these alterations are due in part to reductions in antioxidant defenses. Although intracellular thiols are major redox buffers, their role in maintaining redox homeostasis is not completely understood, particularly during aging, where the reliance on antioxidant enzymes and proteins may b...