UNLABELLED Atypical antipsychotics are widely used in the pharmacologic management of schizophrenia. Information to guide evidence-based clinical decision making must be continually updated, particularly as new clinical trial data and new antipsychotic agents become available. OBJECTIVE This meta-analysis of oral atypical antipsychotics assessed the relative effectiveness and tolerability pro...

INTRODUCTION An ideal antipsychotic would rapidly stabilize acute psychotic symptoms and maintain the patient, without relapse, for prolonged periods in the absence of extrapyramidal, endocrine, diabetic, or cardiovascular side effects, and without weight gain. The dopamine partial agonist aripiprazole is compared with this ideal and with conventional antipsychotics, such as haloperidol, and wi...

Objective: Although atypical antipsychotics are well-tolerated and eff ective treatment options for schizophrenia, they have metabolic side eff ects, including weight gain and increased risk of Type II Diabetes Mellitus (DM). Adiponectin, produced exclusively in adipocytes, is the most abundant serum adipokine. Low levels of adiponectin are correlated with DM, insulin resistance and coronary he...

Intramuscular formulations of antipsychotics can be sub-divided into two groups on the basis of their pharmacokinetic features: short-acting preparations and long-acting or depot preparations. Short-acting intramuscular formulations are used to manage acute psychotic episodes. On the other hand, long-acting compounds, also called "depot", are administered as antipsychotic maintenance treatment ...

The use of antipsychotics in schizophrenic patients often causes side effects the form Extra Pyramidal Syndrome (EPS), namely presence uncontrolled muscle movement disorders such as seizures, shaking and so on. incidence EPS is more common with typical than atypicals. This study aims to see inpatients schizophrenia at Aceh Mental Hospital located Banda 2020. population this were all who given a...

Recent evidence linking hyperprolactinaemia to longer-term clinical sequelae, including osteoporosis, hip fractures and possibly breast cancer, is increasing clinical awareness of the relevance of hyperprolactinaemia. A review of the literature finds clinical trials reporting some degree of comparative prolactin data among antipsychotics. Many of the randomised clinical trials (RCTs) do not rep...

PURPOSE This survey of Italian psychiatrists was conducted to better define drivers of schizophrenia treatment choice in real-life practice, particularly for use of long-acting injectable (LAI) antipsychotics. METHODS Between October 15 and December 15, 2014, 1,000 surveys were sent to psychiatrists who treat schizophrenic patients; 709 completed questionnaires were analyzed (71% response rat...

ED FROM Ray WA, Chung CP, Murray KT, et al. Atypical antipsychotic drugs and the risk of sudden cardiac death. N Engl J Med 2009;360:225–35. Correspondence to: Dr Wayne A Ray, Department of Preventative Medicine, Village at Vanderbilt, Suite 2600, 1501 21st Avenue South, Nashville, TN 37212, USA; [email protected] Source of funding: National Heart, Lung, and Blood Institute and the Age...