Background. Antituberculosis multidrug regimens have been associated with increased incidence of adverse drug reactions (ADRs). This study aimed to determine the incidence and associated factors of ADRs due to antituberculosis therapy. Methods. This is a retrospective cross-sectional study on tuberculosis patients who were treated in tuberculosis clinics in Markazi province in Iran. The informa...

OBJECTIVE To determine the drug resistance profile of Mycobacterium tuberculosis in Mozambique. METHODS We analyzed secondary data from the National Tuberculosis Referral Laboratory, in the city of Maputo, Mozambique, and from the Beira Regional Tuberculosis Referral Laboratory, in the city of Beira, Mozambique. The data were based on culture-positive samples submitted to first-line drug susc...

Tuberculosis is still a major health problem worldwide and one of the main causes of death by a single infectious agent. Only few drugs are really effective to treat tuberculosis, hence, the emergence of multiple, extensively, and totally drug resistant bacilli compromises the already difficult antituberculosis treatments. Given the persistent global burden of tuberculosis, it is crucial to und...

The paper notes that after the formation of Virgin Lands area in December 1960, local health authorities faced a pressing issue solving problems tuberculosis spread among population, as well people resettled there. Tuberculosis, like other infectious diseases, was widespread Kazakhstan. establishment dispensaries and creation fluorography X-ray machines have provided an opportunity to expand pr...

recurrence of pulmonary tuberculosis and was started on the same four medications at a local clinic. One day after the initiation of this treatment, he noted jaundice, abdominal pain and oliguria. Admission laboratory data were as follows: blood urea nitrogen, 71.6mg/dl (25.5mmol/l); creatinine, 5.2mg/dl (459mmol/l); albumin, 4.0 g/dl (40 g/l); total bilirubin, 14.0mg/dl (238mmol/l); direct bil...

BACKGROUND In vitro and animal studies have shown that moxifloxacin-containing combinations may improve the bactericidal efficacy of antituberculosis regimens. PATIENTS AND METHODS We measured the decline in the sputum viable count of 13 patients who were given a combination of moxifloxacin 400 mg daily and isoniazid 300 mg daily. RESULTS The time required to reduce the viable count by 50% ...

Nicotinamide has been found to possess a marked suppressive activity in experimental tuberculosis and , in murine leprosy. The antituberculosis activity of its isomeric derivatives, the isonicotinylhydrazines, has been extensively studied in recent years, both experimentally and in the clinic. Clinical trials of the original compound, nicotinamide, have been limited but favorable results have b...