Peng and colleagues describe the effects of PTEN inactivation on antitumor immunity and response to immune checkpoint blockade in melanoma. These results shed light on the intricate interplay between oncogenic pathways and antitumor immune response.

Do cancer patients responding to immunotherapy have immunological profiles that influence the therapeutic outcome, or do they develop efficient antitumor responses only upon immunotherapy? We came across this "chicken or the egg" dilemma when treating secondary liver tumors with Semliki Forest viruses expressing interleukin-12. In our system, the "egg," that is, the pre-treatment immunological ...

In this work, we study the electrochemical behaviour of skatole, one of the compounds responsible for the offensive smell in pork meat that is known as boar taint, at different metal and carbon electrodes. We then demonstrate for the first time that skatole and indole, the main electroactive interferent potentially present in real samples, can be discriminated and separately quantified using ch...

A drug provocation test (DPT) is the controlled administration of a drug in order to diagnose drug hypersensitivity reactions. DPTs are performed under medical surveillance, whether this drug is an alternative compound, or structurally/pharmacologically related, or the suspected drug itself. DPT is sometimes termed controlled challenge or reexposure (1), drug challenge (2), graded (2) or increm...

The effectiveness of heat therapy in combination with i -(2chboroethyl)-3-cycbohexyl-1-nitrosourea on a murine ependy mobbastomawas investigated. Based on survival time and the number of survivors, whole-body hyperthermia (40°)increased the therapeutic effectiveness of 1-(2-chboroethyb)-3-cycbohexyl 1-nitrosourea. Heat alone did not modify the course of the tumor. Microscopic evidence of accel...

EXPLORATION OF CANCER PROLIFERATIVE SIGNALING IN CHEMOTHERAPYDRUG RESISTANCE AND MDIG-INDUCED TUMORIGENESIS