OBJECTIVE To investigate the pattern and trends of use of antipsychotics, antidepressants, hypnotics and anxiolytics in Alzheimer's disease and other dementias and in patients treated with antidementia medications. DESIGN Cohort study with dementia patients formed in the UK Clinical Practice Research Datalink. Participants Patients with incident dementia, between 1995 and 2011 and a reference...

T HE UBIQUITY OF ANXIETY is reflected by the fact that 18% of Americans had an anxiolytic prescribed in 1972, and 6% had more than 2 mo of continuous exposure to a benzodiazepine. Much of the literature on pharmacologic models of anxiety, especially that relating to catecholamines, is quite old and offers a fascinating historical perspective on the modern development of biologic psychiatry. Thi...

According to the National Institute of Statistics, Geography and Computer Sciences (INEGI, Spanish acronym), in 2003, the method employed in suicide attempts was mostly drug ingestion. The ratio of adolescent boys and girls between 10 and 14 years old involved in suicide attempt is 1:1.3, while the ration of those in the same age range that successfully committed the suicide was 5 males:1 femal...

A recent study (Henriques-Alves and Queiroz, 2015) has critically evaluated traditional and novel behavioral endpoints in this model, calling for assessing multiple behaviors (rather than single indices) in longer test sessions to correctly interpret behavioral data. In line with the renowned psychopharmacologist Prof. Slava Lapin (" one experiment is not an experiment; one behavior is not a mo...

This chapter focuses on considerations in prescribing psychoactive medications for women. Women present to physicians more often and have higher rates of anxiety and depression than do men. Psychotropic medications are prescribed for women nearly twice as much as they are for men, but there is little research information on the differences in drug effects between men and women. Among the most f...

Background. There is little knowledge regarding the characteristics of women treated with hypnotic benzodiazepine receptor agonists (HBRAs) during pregnancy. In this large Danish cohort study, we characterize women exposed to HBRA during pregnancy. We determined changes in prevalence of HBRA use from 1997 to 2010 and exposure to HBRAs in relation to pregnancy. Methods. We performed a retrospect...

of Public Health Psychotropic drugs, which include antipsychotics, anxiolytics, hypnotics, and antidepressants, are commonly utilised among the elderly. However, drug utilisation in this population is complex due to multiple morbidities, extensive drug utilisation and an increased sensitivity to drugs. Inappropriate utilisation of drugs among the elderly is an issue of great public health impor...

OBJECTIVE to compare psychotropic prescribing in older people with dementia and the general elderly population. DESIGN AND SETTING retrospective population database study in 315 General Practices. SUBJECTS there were 271,365 patients aged > or = 65, of which 10,058 (3.7%) recorded as having dementia. METHODS epidemiology of psychotropic prescribing in older people with and without dementi...

BACKGROUND Mental disorders among older adults are mainly treated with psychotropic drugs. Few of these drugs are, however, prescribed by specialized geriatricians or psychiatrists, but rather from general practitioners (GPs). Socioeconomic inequalities in access to specialist prescribing have been found in younger age groups. Hence, we aimed to investigate whether there are socioeconomic diffe...

OBJECTIVE The objective of this study is to examine how nursing homes changed their use of antipsychotic and other psychoactive medications in response to Nursing Home Compare's initiation of publicly reporting antipsychotic use in July 2012. RESEARCH DESIGN AND SUBJECTS The study includes all state recertification surveys (n = 40,415) for facilities six quarters prior and post the initiation...