Abstract Candidemia caused by Candida spp. is a serious threat in hospital settings being major cause of acquired infection and death possible contributor to Covid-19 mortality. incidence has been rising worldwide following increases fungicide-resistant pathogens highlighting the need for more effective antifungal agents with novel modes action. The membrane-bound enzyme alternative oxidase (AO...

About 600 species of Passiflora are described around the world, which 120 native to Brazil. In present work, phytochemical compounds were analyzed by high-performance liquid chromatography, and antioxidant activities (AOX) measured in pulp P. edulis cincinnata species. The presented a higher bioactive content AOX when compared cincinnata. Citric malic acids main organic found. principal compone...

Treatment experiments of a landfill leachate were performed by wet air oxidation (WAO) with the addition of H2O2 (as free radical promoter), and a Fenton-type (at pH 7) process, in order to compare COD (chemical oxygen demand) and AOX (adsorbable organic halogen) reduction as well as biodegradability enhancement measured by OUR respirometric parameter. The WAO reactions were performed in a batc...

Salicylic acid (SA), a natural defensive signal chemical, and antimycin A, a cytochrome pathway inhibitor, induce resistance to Tobacco mosaic virus (TMV). Pharmacological evidence suggested signaling during resistance induction by both chemicals involved alternative oxidase (AOX), sole component of the alternative respiratory pathway (AP). Roles of the AP include regulation of intramitochondri...

OBJECTIVES To evaluate the effect of Candida albicans mitochondrial respiratory status on antifungal azole susceptibility. METHODS The inhibitors cyanide and salicylhydroxamic acid (SHAM) were each combined with azoles to examine the effect of the combinations on C. albicans. C. albicans strains deleted for the alternative oxidase (Aox) were also examined for susceptibility to azoles and for ...

A simple visual ethanol biosensor based on alcohol oxidase (AOX) immobilised onto polyaniline (PANI) film for halal verification of fermented beverage samples is described. This biosensor responds to ethanol via a colour change from green to blue, due to the enzymatic reaction of ethanol that produces acetaldehyde and hydrogen peroxide, when the latter oxidizes the PANI film. The procedure to o...

Hypoxia in freshwater ecosystems is spreading as a consequence of global change, including pollution and eutrophication. In the Patagonian Andes, a decline in precipitation causes reduced lake water volumes and stagnant conditions that limit oxygen transport and exacerbate hypoxia below the upper mixed layer. We analyzed the molecular and biochemical response of the North Patagonian bivalve Dip...

Pulp and paper industry is one of the major sources of man-made generation of organochlorine compounds. During biological treatment of wastewater, part of organochlorine compounds is discharged with treated effluent and part is retained on biomass and disposed of as waste activated sludge. Due to presence of these compounds, the disposal of biosludge from pulp and paper industry has become an i...

The alternative oxidase (AOX) is a cyanide-resistant oxidase that provides an alternative outlet for electrons from the respiratory electron transport chain embedded in the inner membrane of plant mitochondria. Examination of soybean (Glycine max) plants carrying a GmAOX2b antisense gene showed AOX to have a central role in reproductive development and fecundity. In three independently transfor...

BACKGROUND Treatment of cancer patients with anthracycline antibiotic doxorubicin (DOX) may be complicated by development of acute and chronic congestive heart failure (CHF), malignant arrhythmias and death. The aim of this study was to test whether an aqueous low molecular weight (LMW) extract from cod muscle decreases acute mortality in the mouse model of acute CHF caused by DOX. METHODS A ...