نتایج جستجو برای: apo e4 polymorphism

تعداد نتایج: 117403  

Journal: :Arteriosclerosis and thrombosis : a journal of vascular biology 1992
G Sigurdsson V Gudnason G Sigurdsson S E Humphries

Epidemiological studies have demonstrated that the risk of coronary artery disease (CAD) is increased in smokers but reduced in individuals with elevated plasma levels of high density lipoprotein cholesterol (HDL-C) and apolipoprotein (apo) A-I. In a sample of 315 men and women from Iceland, the mean levels of HDL-C and apo A-I in smokers were, respectively, 12% and 6% lower in men and 7% and 6...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2000
Björn Lundahl T P Leren L Ose A Hamsten F Karpe

The microsomal triglyceride transfer protein (MTP) has a key function in intracellular apolipoprotein (apo) B lipidation and secretion of very low density lipoprotein (VLDL). A recently discovered functional polymorphism in the promoter of the MTP gene (-493G/T) affects the plasma concentration of low density lipoprotein (LDL) cholesterol and the VLDL distribution between large and small partic...

Journal: :Neurology 2015
Stefan Hähnel Christian Herweh

In this issue of Neurology®, Huang et al. describe a higher prevalence of cerebral microbleeds in patients with mild traumatic brain injury (mTBI) in comparison to healthy controls using susceptibility-weighted MRI. They could also link these observations to neuropsychological deficits as measured by the digit span score, in comparison to patients with mTBI without microbleeds. This report alig...

Journal: :European journal of endocrinology 2002
Ivana Zofková Katerina Zajícková Martin Hill Ales Horínek

OBJECTIVE Apolipoprotein E (ApoE) is believed to play an important role in lipid metabolism and has been found to be related to diseases associated with ageing, the important characteristic of which is decline in circulating sex steroids, including androgen. DESIGN To find the relationships of levels of serum testosterone and its precursor, dehydroepiandrosterone (DHEA), to ApoE polymorphism ...

2016
Fariba Koohdani Haleh Sadrzadeh-Yeganeh Mahmoud Djalali Mohammadreza Eshraghian Elham Zamani Gity Sotoudeh Mohammad Ali Mansournia Laleh Keramat

BACKGROUND Apolipoprotein A2 (APO A2) is the second most abundant structural apolipoprotein in high density lipoprotein. Several studies have examined the possible effect of APO A2 on atherosclerosis incidence. Due to the role of inflammation in atherosclerosis, we aimed to determine the relationship between APO A2 -265T/C polymorphism and inflammation as a risk factor in type 2 diabetes mellit...

Journal: :Pharmacognosy Journal 2023

Background: Recurrent cardiovascular disease (CVD) incidence puts patients at higher risk for mortality and morbidity. One of the CVD symptoms is acute coronary syndrome (ACS). Many genetic polymorphisms are factors. This study’s purpose was to investigate correlation between recurrent ACS apolipoprotein E (ApoE) gene polymorphism. Method: Case-control design used in this study. About 90 who vi...

2013
Sachi Jain Seo Yeon Yoon Laura Leung Johanna Knoferle Yadong Huang

Apolipoprotein (apo) E4 is the leading genetic risk factor for Alzheimer's disease (AD), and it has a gene dose-dependent effect on the risk and age of onset of AD. Although apoE4 is primarily produced by astrocytes in the brain, neurons can also produce apoE4 under stress conditions. ApoE4 is known to inhibit neurite outgrowth and spine development in vitro and in vivo, but the potential influ...

2017
Magdalena M Misiak MariaMananita S Hipolito Habtom W Ressom Thomas O Obisesan Kebreten F Manaye Evaristus A Nwulia

Alzheimer's disease (AD) is the most common form of dementia that affects more than 5 million Americans. It is the only disease among the 10 causes of death that cannot be slowed or cured, thus raising the need for identification of early preclinical markers that could be the focus of preventative efforts. Although evidence is escalating that abnormalities in olfactory structure and function pr...

Journal: :Arquivos brasileiros de cardiologia 2002
Carla Helena Augustin Schwanke Ivana Beatrice Mânica da Cruz Ney Furhmann Leal Rosane Scheibe Yukio Moriguchi Emílio Hideyuki Moriguchi

OBJECTIVE To establish the allelic and genotypic frequencies related to apolipoprotein E (ApoE) polymorphism and association of the genotypes with risk factors and cardiovascular morbidity in an elderly population with longevity. METHODS We analyzed 70 elderly patients aged 80 years or more who were part of the Projeto Veranópolis. We used the gene amplification technique through the polymera...

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