In the pharmaceutical world, an impurity is considered as any other organic material, besides the drug substance, or ingredients, arise out of synthesis or unwanted chemicals that remains with API’s. Impurity profiling is the process of acquiring and evaluating data that establishes biological safety of an individual impurity; thus, revealing its need and scope in pharmaceutical research. The c...

Formulators are charged with the responsibility to formulate a bioequivalent product (in case of ANDA) product which is physically and chemically stable, manufacturable at commercial scale. Different crystal structures in polymorphs arise when the drug substance crystallizes in different crystal packing arrangements and/or different conformations. Besides, Polymorphs cocrystallization is now im...

Crystallization of active pharmaceutical ingredient (API) or pharmaceutical drug substances is a crucial unit operation. In this paper challenges and scientific progress over the last two decades in the areas of pharmaceutical crystallization thermodynamics, kinetics, polymorphism, process modeling, and process control were attempted. Effective utilization of such scientific knowledge for optim...

Granulation methods are used in the pharmaceutical sector to enlarge and densify small powder particles into larger ones, typically to improve powder flow so that the material can be processed effectively and efficiently into solid dosage forms. In addition, granulation methods are important for “locking in” the API within the formulation, thereby reducing the risk of segregation. Granulated ma...

Quality by Design (QbD) is a newer paradigm being widely implemented by pharmaceutical industries for producing robust drug products with consistency in their quality as per the predefined objectives. The QbD approach emphasizes on building quality from the beginning and helps developing products that meets the consumer and regulatory requirements. QbD in pharmaceutical formulation and developm...

OBJECTIVE Implantable brain-computer interface (BCI) research promises improvements in human health and enhancements in quality of life. Informed consent of subjects is a central tenet of this research. Rapid advances in neuroscience, and the intimate connection between functioning of the brain and conceptions of the self, make informed consent particularly challenging in BCI research. Identifi...

In this paper we present a client/server-based un-intrusive collaborative multimedia application called eMeeting that extracts and archives salient visual information from seminars, while allowing interaction among presenters and the audience in real time. The application uses API's of the Lotus Sametime system such as secure login, directory, meeting and multimedia services, to which we have a...

Introduction: Poor aqueous solubility of an active pharmaceutical ingredient (API) is one of the most pressing problems in pharmaceutical R&D, with as many as 90% of new API candidates in this category (Lobmann et al., 2013). Dissolution rate in the gastrointestinal tract is the rate limiting factor for the absorption of many of these drugs (Zimmermann et al., 2009), which may limit their bioav...

We have implemented and evaluated a method to populate a company ontology, focusing on hierarchical relations such as acquisitions or subsidiaries. Our method searches for information about user-specified companies on the Internet using a search engine API (Google Custom Search API). From the resulted snippets we identify companies using machine learning and extract relations between them using...

Writing is an important activity in academic and corporate environments. Feedback on the writing is key to improving the quality of documents, and for novice writers to develop their skills. This paper describes the architecture of a web-based framework for providing automated feedback. The framework allows writers to use different writing tools such as Wiki’s, cloud-based Google Docs or Word. ...