Sea cucumbers have been a dietary delicacy and important ingredient in Asian traditional medicinal over many centuries. In this study, edible sea cucumber Holothuria edulis was evaluated for its in vitro anticancer potential. An aqueous fraction of the edible sea cucumber (ESC-AQ) has been shown to deliver a strong cytotoxic effect against the human HL-60 leukaemia cell line. An induction effec...

We examine the role of target firms’ accruals quality (AQ) on the course of the acquisition process. We predict and find that target AQ is significantly associated with the choice of sales method (auction vs. negotiation), acquirer and target returns, the likelihood of deal completion, and the speed of the process overall. We further find that AQ has a more pronounced effect on M&A transactions...

It has been demonstrated that continuous exposure to amodiaquine (AQ) alone elicits in vitro antischistosomal activities at concentrations of 1-10 μg/ml. However, orally administered drugs reach a peak blood concentration within one or two hours and then gradually decrease. The blood concentration does not remain at a constant level over several days as in vitro concentration of continuous drug...

Resistance of Plasmodium falciparum (Pf) and P. vivax (Pv) to standard antimalarials is widespread in Papua New Guinea (PNG). The objective of the study was to assess the rate of clinical treatment failure (TF) and parasite resistance to amodiaquine (AQ), chloroquine (CQ) and quinine+sulfadoxine/pyrimethamine (Q+SP) for malaria in a rural health centre of the East Sepik Province. 179 patients p...

soda and soda-aq pulping of corn stalk applying different charges of active alkali and pulping time was studied. the average value of fiber length, diameter and cell wall thickness were measured as 1.03 mm, 23.64 µm and 5.26 µm, respectively. the content of alcohol-acetone extractives, cellulose, lignin, extractives soluble in 1% naoh and ash content of corn stalk were determined as 15%, 51.2%,...

Antimalarial drugs with the 4-aminoquinoline scaffold such as the important drugs, chloroquine (CQ) and amodiaquine (AQ), have been used to prevent and treat malaria for many years. The importance of these drugs is related to their simple usage, high efficacy, affordability, and cost-effectiveness of their synthesis. In recent years, with the spread of parasite resistance to CQ and cross-resist...

Microbial dissimilatory iron reduction (DIR) is widespread in anaerobic sediments and is a key producer of aqueous Fe(II) in suboxic sediments that contain reactive ferric oxides. Previous studies have shown that DIR produces some of the largest natural fractionations of stable Fe isotopes, although the mechanism of this isotopic fractionation is not yet well understood. Here we compare Fe isot...

Background and aims: Cutaneous leishmaniasis is a major health issue in many parts of Iran.Diagnosis of cutaneous leishmaniasis in a non-endemic area is not as simple as that in endemic foci.The management and treatment of this disease are global dilemmas. The purpose of this study was toidentify Leishmania species isolated from human cutaneous leishmaniasis lesions in patient...

Aquagenic urticaria (AQ) is a rare physical urticaria induced by contact with water. It may be distinctive clinically, evident as 1-2 mm folliculopapular urticaria, a pattern also characteristic of cholinergic urticaria. AQ has a truncal and upper extremity distribution within 20-30 minutes after contact with water, regardless of its temperature or source. AQ is usually symptomatic with mild to...