OBJECTIVE To examine the association between frequent gouty arthritis and the presence of absolute/relative contraindications to gout therapies, and health-care expenditure associated with frequent gouty arthritis. METHODS This retrospective study used administrative claims to identify patients with gouty arthritis between 1 July 2005 and 30 June 2010. Patients with ≥3 yearly gouty arthritis ...

Obesity is pandemic in the Western Hemisphere, especially in the United States (US) and is associated with morbidity and mortality. Recent data show that a large proportion of the US population is at least overweight and almost 2 in 5 Americans are obese. This ongoing trend of increasing obesity rates has led to a thriving market for anorexigens. Despite the health benefits of weight loss, seve...

The effects of topical application of the carbonic anhydrase inhibitor trifluormethazolamide (TFM) on intraocular pressure (IOP), ascorbate and CO2 concentrations in aqueous humor, and aqueous humor flow were studied in rabbits. These effects were compared with those produced by systemic treatment with methazolamide. The decrease in IOP observed after TFM was accompanied by changes in the compo...

OBJECTIVE To determine the therapeutic efficacy of adjuvant use of voriconazole, 1%, eyedrops in the treatment of refractory fungal keratitis. METHODS A prospective open-label trial was conducted to determine voriconazole levels obtained in human aqueous humor after administration of a 1% solution, preserved with 0.01% benzalkonium chloride, every 6 hours for 3 days, or hourly for 4 doses. Te...

The distribution of cyclosporin A (CsA) in the blood, saliva, tears, aqueous humour, vitreous, and cerebrospinal fluid has been studied after oral treatment with 5 mg/kg/day of CsA or application of 2% CsA eye drops in olive oil solution. After oral treatment all patients had high CsA levels in blood. Measurable levels of CsA were also found in the saliva and tears. Patients without any intraoc...

THE unsatisfactory state of our knowledge regarding the effect of cortisone on capillary permeability has been discussed in a previous paper (Duke-Elder and Ashton, 1951). It was there noted that Leopold and others (1951), injecting fluorescein intravenously in rabbits and estimating its concentration in the aqueous humour, observed no delay in the appearance of the dye in the anterior chambers...

PURPOSE To investigate the penetration of tacrolimus to the aqueous and serum after topical and oral administration. METHODS Thirty Wistar rats were divided into three groups. In the first group (n = 12), a single dose of 0.3 % isotonic tacrolimus solution was applied topically to the rat eyes. The second group (n = 12), received 0.1 mg/kg/day tacrolimus for three days. In control group (n = ...

Exogenous corticosteroids (dexamethasone, cortisol) inhibit the adrenal secretion of corticosterone in the rabbit and decrease the concentration of corticosterone in aqueous humour, increase glycaemia and cause a rise in glucose concentration in the aqueous. Except for a slight rise 16 h after the corticosteroid administration no effect on plasma or aqueous content of total protein was observed...