Therapeutic Drug Monitoring (TDM) of first-line anti-tuberculosis (TB) drugs is a decisive tool, allowing the clinician to successfully treat TB patients. The objective of the study was to develop and optimize a simple, sensitive, and reliable high-performance liquid chromatography (HPLC) method for the simultaneous determination of isoniazid (INH), pyrazinamide (PZA), and rifampin (RIF) levels...

In this paper we describe block algorithms for the reduction of a real symmetric matrix to tridiagonal form and for the reduction of a general real matrix to either bidiagonal or Hessenberg form using Householder transformations. The approach is to aggregate the transformations and to apply them in a blocked fashion, thus achieving algorithms that are rich in matrix-matrix operations. These red...

Chitosan with excellent biodegradable and biocompatible characteristics has received attention as an oral drug delivery vehicle for controlled-release formulations. In this study an enteric-coated capsule containing theophylline-chitosan beads based on 23 factorial designs was prepared as a colon drug delivery system. The theophylline-chitosan gel beads were formulated by adding the drug-contai...

objective(s):despite of wide range applications of polymeric nanoparticles in protein delivery, there are some problems for the field of protein entrapment, initial burst and controlled release profile.   materials and methods: in this study, we investigated the influence of some changes in plga nanoparticles formulation to improve the initial and controlled release profile. selected parameters ...

The aim of the paper is to analyze electro-thermo nonlinear vibration of a double-piezoelectric composite microplate-system (DPCMPS) based on nonlocal piezoelasticity theory. The two microplates are assumed to be connected by an enclosing elastic medium which is simulated by Pasternak foundation. Both of smart composite microplates are made of poly-vinylidene fluoride (PVDF) reinforced by zigza...

A receiver-spoofer is one of the most covert global navigation satellite system (GNSS) spoofing attacks and can only be effectively detected by the combination of multiple anti-spoofing technologies. In this paper, an analysis of influencing parameters for receiver-spoofers indicates that the ratio of the spoofing signal amplitude versus the authentic signal amplitude (spoofing-signal ratio) is...

in this study, mixed metal oxides al2o3/mgo/tio2 coatings with al/mg/ti ratio of 5:1:3 and 2.5:3:4 were coated on aluminum by sol-gel method. the surface morphology, phase analysis, thermal behavior and the corrosion behavior of the al2o3/mgo/tio2 coatings were characterized by (sem), (xrd), (tg-dta) and potentiodynamic polarization test in 3.5 wt.% nacl solution. the results demonstrated that ...