نتایج جستجو برای: archival breast cancer tissues
تعداد نتایج: 1151518 فیلتر نتایج به سال:
Arylamine N-acetyltransferase type 1 (NAT1) is reported to be involved in the transfer of an acetyl group from acetyl-CoA to the terminal nitrogen of hydrazine and arylamine drugs or carcinogens. Gene-specific hypomethylation frequently occurs in a range of cancers and hypomethylation of the genes often correlates well with increased transcription levels. This study was conducted in order to ev...
background: to reduce the dose to normal tissues surrounding the treated breast, a uniform magnetic field was used within a humanoid phantom in breast radiotherapy. materials and methods: monte carlo simulations were performed with geant4, irradiating humanoid phantoms in a magnetic field. to reconstruct phantoms, computed tomography (ct) data slices of four patients were used for the monte car...
PURPOSE We investigated the expression of human endogenous retroviral (HERV) sequences in breast cancer. EXPERIMENTAL DESIGN Reverse transcription-PCR (RT-PCR) was used to examine expression of the envelope (env) region of ERV3, HERV-E4-1, and HERV-K in breast cancer cell lines, human breast tumor samples, adjacent uninvolved breast tissues, nonmalignant breast tissues, and placenta. Expressi...
Breast cancer is the most common cause of cancer death among women under age 50 years, so it is imperative to identify molecular markers to improve diagnosis and prognosis of this disease. Here, we present a new approach for the identification of breast cancer markers that does not measure gene expression but instead uses the ratio of alternatively spliced mRNAs as its indicator. Using a high-t...
PURPOSE Golgi phosphoprotein 3 (GOLPH3) has been reported to be involved in various biologic processes. The clinical significance and biologic role of GOLPH3 in breast cancer, however, remains unknown. EXPERIMENTAL DESIGN Expression of GOLPH3 in normal breast cells, breast cancer cells, and 6-paired breast cancer and adjacent noncancerous tissues were quantified using real-time PCR and Wester...
objective: azadirachta indica (neem) has been used traditionally for many centuries. some impressive therapeutic qualities have been discovered. however, the therapeutic effect of neem leaf extract in 4t1 breast cancer has not been documented. the purpose of the present study is to investigate the therapeutic effect of ethanolic neem leaf extract in an in vivo 4t1 breast cancer model in mice. m...
BACKGROUND Genome-wide miRNA expression may be useful for predicting breast cancer risk and/or for the early detection of breast cancer. RESULTS A 41-miRNA model distinguished breast cancer risk in the discovery study (accuracy of 83.3%), which was replicated in the independent study (accuracy = 63.4%, P=0.09). Among the 41 miRNA, 20 miRNAs were detectable in serum, and predicted breast cance...
BACKGROUND MicroRNA-101 (miR-101) expression is negatively associated with tumor growth and blood vessel formation in several solid epithelial cancers. However, the role of miR-101 in human breast cancer remains elusive. RESULTS MiR-101 was significantly decreased in different subtypes of human breast cancer tissues compared with that in adjacent normal breast tissues (P<0.01). Up-regulation ...
breast conservation surgery combined with radiation therapy is now an accepted option for the treatment of early breast cancer. so we decided to evaluate the results of such treatment in our first group of patients treated by this method. from 1992 to 1996 , one hundred patients with stage i and ii breast cancer treated with breast conservative surgery (lumpectomy or quadrantectomy). were irrad...
Despite marked advances in breast cancer therapy, breast cancer-associated leptomeningeal metastasis (LM), a particularly aggressive syndrome with multifocal seeding of the leptomeninges by tumor cells, still carries an abysmal prognosis. A major problem with breast cancer LM surveillance is the lack of an effective and sensitive means to track dynamic changes of the disease. Cytology detection...
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