نتایج جستجو برای: area under curve
تعداد نتایج: 1629228 فیلتر نتایج به سال:
BACKGROUND Genomewide association studies have identified multiple genetic variants associated with breast cancer. The extent to which these variants add to existing risk-assessment models is unknown. METHODS We used information on traditional risk factors and 10 common genetic variants associated with breast cancer in 5590 case subjects and 5998 control subjects, 50 to 79 years of age, from ...
OBJECTIVE The aim of the study was to determine the longitudinal validity, reproducibility, responsiveness and interpretability of the adult version of the Brisbane Burn Scar Impact Profile, a patient-report measure of health-related quality of life. METHODS A prospective longitudinal cohort study of patients with or at risk of burn scarring was conducted at three assessment points (at baseli...
BACKGROUND External validation on different TBI populations is important in order to assess the generalizability of prognostic models to different settings. We aimed to externally validate recently developed models for prediction of six month unfavourable outcome and six month mortality. METHODS The International Neurotrauma Research Organization - Prehospital dataset (INRO-PH) was collected ...
The effects of immobilization stress on the pharmacokinetics of omeprazole were studied in rats. The immobilization stress for 30 or 60 min immediately after oral administration of the drug caused an increase in the time to reach the maximum concentration. However, such stress did not alter the area under the plasma concentration-time curve (AUC). When administered intravenously, the half-life ...
In light of the concept of the mutant selection window, i.e., the range between the MIC and the mutant prevention concentration (MPC), MPC-related pharmacokinetic indices should be more predictive of bacterial resistance than the respective MIC-related indices. However, experimental evidence of this hypothesis remains limited and contradictory. To examine the predictive power of the ratios of t...
The effect of food on the absorption of amoxicillin and ampicillin was studied in 16 normal subjects in a double-blind crossover study after each subject was given a single oral 500-mg dose. Serum drug levels were analyzed, assuming a one-compartment linear model with first-order absorption and absorption delay, area under the curve, and urinary recovery. Variations in kinetic parameters were e...
The area under the ROC curve (AUC) is a well-known measure of ranking performance, and is also often used as a measure of classification performance, aggregating over decision thresholds as well as class and cost skews. However, David Hand has recently argued that AUC is fundamentally incoherent as a measure of aggregated classifier performance and proposed an alternative measure [5]. Specifica...
OBJECTIVE To describe the long-term course of depressive symptoms up to 3 years post-stroke and to develop a prediction model for depressive symptoms 1 and 3 years post-stroke. DESIGN Longitudinal follow-up study. PATIENTS Data were analysed for 131 patients with a first-ever supratentorial stroke admitted for inpatient rehabilitation in the Netherlands METHODS The Center for Epidemiologi...
This article focuses on parameter estimation of multilevel nonlinear mixed-effects models (MNLMEMs). These models are used to analyze data presenting multiple hierarchical levels of grouping (cluster data, clinical trials with several observation periods, ...). The variability of the individual parameters of the regression function is thus decomposed as a between-subject variability and higher ...
PURPOSE Colposcopy occupies a key role in the prevention of cervical cancer by identifying preinvasive or invasive lesions. However, colposcopy is subjective and is responsible for 52% of screening failures. Dynamic spectral imaging (DSI) is based on the objective, quantitative assessment of the acetowhitening effect. This study compared DSI with colposcopy. EXPERIMENTAL DESIGN Women referred...
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