Pharmacological treatment is the cornerstone therapy of heart failure with reduced ejection fraction (HFrEF). In addition, several percutaneous techniques have been developed to treat symptomatic patients, specific (HF) phenotypes (e.g., valvular disease) that require non-pharmacological treatment. Given their prognostic relevance, it imperative deliver high-level patient care. This review prov...

Beta-blockers are the cornerstone of treatment for various cardiovascular conditions. were discovered as antianginal drugs in 1960s and currently widely used heart failure, arrhythmias, ischemic disease. In this article, we review evidence beneficial effects beta-blockers these conditions, well current recommendations clinical practice guidelines their use. Surprisingly, despite having been pre...

Bariatric surgery procedures are increasing exponentially with the obesity epidemic. Early complications defined as those that occur within first 30 days after surgery. Some of most common early leaks, bleeding, stricture or stenosis and bezoar, all which can be diagnosed treated endoscopically. Upper endoscopy has been proven to safe in postoperative period different endoscopic modalities, lik...

In this review, we summarize the current “state of art” carbapenem antibiotics and their role in our antimicrobial armamentarium. Among beta-lactams currently available, carbapenems are unique because they relatively resistant to hydrolysis by most beta-lactamases. Herein, described cost effectiveness, safety, advantages as compared other antibiotics. We also highlight important features that p...

We describe a patient with advanced young-onset Alzheimer’s disease whose intractable behavioral disturbance and agitation responded to short acting opioid medications after failure of multiple other medications and nonpharmacological methods of treatment. Opioids are a little explored but potentially useful addition to the armamentarium of tools for managing severe agitation in patients with d...

The purpose of this article is to review recent advances in the treatment of epilepsy. It includes five antiepileptic drugs that have been recently added to the pharmacologic armamentarium and surgical techniques that have been developed in the last few years. Finally, we review ongoing research that may have a potential role in future treatments of epilepsy.

Over the last decade, prosthetic-based breast reconstruction has been revolutionized with technological advancements. Reconstructive surgeons now have a multitude of prosthetic devices and tissue expanders, tools for intraoperative perfusion analysis, implantable bioprosthetic materials and a technique for autoaugmentation within their armamentarium to reconstruct natural breasts today like nev...

A novel oligoamine analog inhibitor of histone demethylases blocks colon tumor cell growth in association with histone methylation and gene re-expression. It also markedly potentiates the activity of hypomethylating agents in vitro and in vivo, suggesting that histone demethylase inhibitors may represent a valuable addition to the armamentarium of epigenetic agents. (Clin Cancer Res 2009;15(23)...

A well executed transseptal puncture is crucial for successful percutaneous transvenous mitral balloon valvotomy. We report a case of accidentally damaged Mullins sheath dilator. Due to immediate unavailability of another dilator at cardiac catheterization laboratory, angioplasty guidewire and balloon was used as an additional assisting armamentarium for successful percutaneous transvenous mitr...

A novel oligoamine analog inhibitor of histone demethylases blocks colon tumor cell growth in association with histone methylation and gene re-expression. It also markedly potentiates the activity of hypomethylating agents in vitro and in vivo, suggesting that histone demethylase inhibitors may represent a valuable addition to the armamentarium of epigenetic agents.