We examine the effects of different forms of feedback information on the performance of markets that suffer from moral hazard problems due to sequential exchange. As orthodox theory would predict, we find that providing buyers with information about sellers’ trading history boosts market performance. More sursprisingly, this beneficial effect of incentives for reputation building is considerabl...

Background The A2A adenosine receptor is a member of the G proteincoupled receptor family. It is known to posses several unique structural and functional features that differ from established signaling paradigms. Recently, the exceptionally long (>120 amino acids) C-terminus of the receptor has raised interest for its capacity to act as a binding site for several "accessory" proteins. In search...

In Republics of Knowledge : Nations the Future in Latin America , Nicola Miller, Professor American history at University College London, offers a two-part book addressing knowledge Spanish from independence 1810 to 1910, when governments understood importance access public as key feature modern nations. From multipractice perspective, Miller addresses contribution by different people, institut...

Martine Puylaert, MD, FIPP*; Leonardo Kapural, MD, PhD, FIPP; Jan Van Zundert, MD, PhD, FIPP*; Dirk Peek, MD; Arno Lataster, MSc; Nagy Mekhail, MD, PhD, FIPP**; Maarten van Kleef, MD, PhD, FIPP; Yolande C. A. Keulemans, MD, PhD *Department of Anesthesiology and Multidisciplinary Pain Centre, Ziekenhuis Oost-Limburg, Genk, Belgium; Department of Anesthesiology, School of Medicine, Wake Forest Un...

Background The A2A adenosine receptor is a prototypical G proteincoupled receptor. It is expressed in a wide variety of cells including as different types as neurons, platelets, cells of the immune system and muscle. The cell-specific expression of the A2A adenosine receptor is controlled by at least three different upstream non-coding exons and their corresponding promotors. Compared to other ...

The goal of the FID/LD Workshop on Linguistics and Information Science was to contribute to the development of a comprehensive plan that can be used to guide research activities for more effective use of linguistics in information science. To appreciate our progress toward that goal during the.three days at Biskops-Arno in May of 1976, it is necessary to consider in some detail the stimulus tha...

Two approaches toward the arrow of time for scattering processes have been proposed in rigged Hilbert space quantum mechanics. One, due to Arno Bohm, involves preparations and registrations in laboratory operations and results in two semigroups oriented in the forward direction of time. The other, employed by the Brussels-Austin group, is more general, involving excitations and de-excitations o...

Sec7-related guanine nucleotide exchange factors (GEFs) initiate vesicle budding from the Golgi membrane surface by converting the GTPase ARF to a GTP-bound, membrane-associated form. Here we report the crystal structure of the catalytic Sec7 homology domain of Arno, a human GEF for ARF1, determined at 2.2 angstroms resolution. The Sec7 domain is an elongated, all-helical protein with a distinc...