gens in the neoplastic processes induced by these compounds. The fact that the aromatic aminoazo dyes are carcinogenic primarily in the liver and generally not at sites of local application (16) has suggested that the aminoazo dyes are likewise active through the formation of reactive metabolites. The structural similarity be tween the aminoazo dyes and the carcinogenic aromatic amines and amid...

gens in the neoplastic processes induced by these compounds. The fact that the aromatic aminoazo dyes are carcinogenic primarily in the liver and generally not at sites of local application (16) has suggested that the aminoazo dyes are likewise active through the formation of reactive metabolites. The structural similarity be tween the aminoazo dyes and the carcinogenic aromatic amines and amid...

Ionic liquid with multi-SO3H groups was employed as a catalyst for facile preparation of 1,8dioxo-decahydroacridines via the one-pot condensation of various aldehydes, 1,3-diketones with aromatic amines or ammonium acetate. Various aromatic aldehydes were utilized in the reaction and in all situations the desired product were synthesized successfully. The described novel synthesis method propos...

A catalyst-free one-pot three component methodology for the synthesis of α-aminonitriles under ultrasonic irradiation at room temperature using [Bmim]Br as a neutral reaction medium is described. A broad range of substrates including the aromatic, heteroaromatic and aliphatic aldehydes were condensed with amines (aliphatic and aromatic) and trimethylsilyl cyanide (TMSCN). Using this method, all...

A convenient, one-pot method for the synthesis of diazonium salt has been developed by the sequential diazotization of aromatic amines with NaNO2, polymer- supported periodic acid (PPIA) and 2-naphthole under solvent-free conditions at room temperature. By using this method, several types of aromatic amine, containing electron-withdrawing and electron-donating groups, were rapidly converted to ...

Genetic susceptibility to bladder cancer in individuals exposed to arylamines may be explained by interindividual metabolic differences that lead to arylamine bioactivation or detoxification. In this article, occupational bladder cancer risk factors and the evidence that links benzidine exposure to bladder cancer are reviewed. Benzidine metabolism is described and compared with that of other ar...

Certain aromatic amines carcinogenic for the human urinary bladder, such as 4-aminobiphenyl, undergo hepatic metabolic activation to N-hydroxylamines, which are transported to the bladder. During the transport process, these reactive species come in contact with hemoglobin and react with this blood protein. The principal hemoglobin adduct formed is a cysteine sulfinamide, and quantitative metho...

Foliar explants of Nicotiana tabacum cv Xanthi n.c. were cultured on four different media: a basal medium, basal medium plus benzyladenine, basal medium plus 2,4-dichlorophenoxyacetic acid (2,4-D), and the basal medium containing both hormones. No differentiation or cell division occurred in leaf explants cultured on the basal medium. Addition of benzyladenine caused the formation of buds on th...

Steady-state irradiation in neat acetonitrile of some aromatic nitriles, imides and esters (10(-5)-10(-3) M solution) in the presence of tertiary amines allowed the accumulation of the corresponding radical anions, up to quantitative yield for polysubstituted benzenes and partially with naphthalene and anthracene derivatives. The condition for such an accumulation was that the donor radical cat...

The concept of chemically mediated synaptic neurotransmission in the central nervous system (CNS) is heavily biased by our still evolving understanding of peripheral cholinergic and sympathetic neurons. The better established amine neurotransmitter candidates (especially acetylcholine, the catecholamines and serotonin) account for only a fraction of the total nerve terminals in the mammalian CN...