Pontes-Arruda and colleagues addressing eicosapenta enoic acid/γ-linolenic acid (EPA/GLA) use in septic patients [1]. First, I did not fi nd an adequate sample size calculation and we should know whether a type I error could have occurred. Another major concern is the inclusion imbalance among sites, which is not mentioned in the results or as a study limitation. Th e authors recognized that on...

recent issues of Critical Care, we read with concern the article by Pontes-Arruda and colleagues [1] and the fi rst author's reply to the letter from Machado (the latter two of which appear in [2]). Th e article and subsequent letters address eicosapentaenoic acid/gamma-linolenic acid (EPA/GLA) use in sepsis patients in the INTERSEPT (Investigating Nutritional Th erapy with EPA, GLA and Antioxi...

Citation: Vangeneugden J, Mazo C and Lepousez G (2015) Commentary: " Posttraining ablation of adult-generated olfactory granule cells degrades odor-reward memories. " Front. Neurosci. 9:110. In the adult brain, hippocampus and olfactory bulb retain the remarkable capacity of generating new neurons and implementing them into existing neural circuitry. This phenomenon, adult neu-rogenesis, result...

Abravanel, Florence Ackermann, Mathias Admon, Arie Afonso, Claudio L. Agbandje-McKenna, Mavis Agol, Vadim I. Aguilar, Hector C. Aguilar, Patricia V. Ahn, Byung-Yoon Ahn, Jin-Hyun Ahn, Jinwoo Ahn, Kwangseog Akari, Hirofumi Alam, S. Munir Albert, Jan Albin, John S. Alcami, Antonio Alcami, José Aldovini, Anna Al-Harthi, Lena Alkhatib, Ghalib Almazan, Fernando Alonso, Sylvie Altan-Bonnet, Nihal Alt...

satisfying experience in science occurs when information from several areas converge to give a big picture about an important problem. In three papers (Holtz-man et al. in this issue of The Journal of Cell Biology, the disciplines of genetics and structural biology have revealed that two ac-tin cross-linking proteins, fimbrin and alpha-actinin, bind to the same region on actin. Because both pro...

Valder R. Arruda, MD, Hematology-Hemotherapy Center, State University of Campinas, CP 6198, BR-13081-970 Campinas, SP (Brazil), Fax+55 19 239 31 81/239 31 14 Autoimmune thrombocytopenic purpura (AITP) is characterized by the development of antibodies against platelet membrane proteins which results in their phagocytosis and destruction by the monocyte-macrophage system [1]. The production of pl...

Anand & Gurtin (2002) have recently developed a continuum theory for the elasticviscoplastic deformation of amorphous solids. Their theory is motivated by and builds on the work of Parks, Argon, Boyce, Arruda, and their co-workers (e.g. Boyce et al., 1988; Arruda & Boyce, 1993) on modeling the plastic deformation of amorphous polymers. The theory of Anand & Gurtin (2002) carefully accounts for ...

Background Neoantigens’ (neoAg) identification, which determines T-cell responses against tumors, has fostered the development of personalized vaccines with promising results. While ranking most immunogenic neoAg can be addressed using predictive techniques, their formulation as needs to improved. To maximize therapeutic potential, optimal neoAg-based should manufactured in a superb delivery pl...