The degree of binding of a drug to plasma proteins has a marked effect on its distribution, elimination, and pharmacological effect since only the unbound fraction is available for distribution into extra-vascular space. The protein-binding of atenolol was measured by equilibrium dialysis in the bovine serum albumin (BSA). Free atenolol concentration was increased due to addition of arsenic whi...

Compared to the large number of main group Zintl compounds there are only a few that contain transition metals.[1] This is not surprising since the traditional definition of Zintl phases automatically excludes transition metals. However, many such compounds with transition metals can qualify for Zintl phases when a broader definition is used. The latter includes compounds of transition metals w...

Although epidemiologic studies have linked arsenic exposure to the development of human cancer, the mechanisms underlying the tumorigenic role of arsenic remain largely undefined. We report here that treatment of cells with sodium arsenite at the concentrations close to environmental exposure is associated with the up-regulation of Hdm2 and the accumulation of p53 in the cytoplasm. Through the ...

The toxicological and human health effects caused by arsenic exposure were first described centuries ago, yet there are still many areas of inquiry that have not been elucidated, particularly with respect to the mechanisms of action of arsenic and the factors that may affect susceptibility to the damaging effects of this element and its compounds. These and other related areas are the topics of...

Links between environmental chemicals and human health have emerged, but the effects on sleep health were less studied. Therefore, the aim of the present study was to investigate the relationships of different sets of environmental chemicals and common sleep troubles in a national and population-based setting. Data were retrieved from the United States National Health and Nutrition Examination ...

In order to find out the effect of organic arsenic compounds in form salvarsan and its derivatives on blood clotting author set a series vitro vivo experiments by methods Brkеrʹa Schultz'a. These convinced that such as already minimal amounts cause retardation.

•ATO rescues multiple p53 mutants effectively in various assays •The structural mechanism of how mutant function is restored by ATO described •Most are stabilized structurally but only some transcriptionally rescued •Widely applicable, yet has individual mutation-based therapeutic potential TP53 the most frequently mutated gene cancer, these mutations remain therapeutically non-actionable. Majo...

Studies that investigate arsenic resistance in the foodborne bacterium Campylobacter are limited. A total of 552 Campylobacter isolates (281 Campylobacter jejuni and 271 Campylobacter coli) isolated from retail meat samples were subjected to arsenic resistance profiling using the following arsenic compounds: arsanilic acid (4-2,048 μg/mL), roxarsone (4-2048 μg/mL), arsenate (16-8,192 μg/mL) and...

Complexes of arsenic compounds and glutathione are believed to play an essential part in the metabolism and transport of inorganic arsenic and its methylated species. Up to now, the evidence of their presence is mostly indirect. We studied the stability and chromatographic behaviour of glutathione complexes with trivalent arsenic: i.e. As(GS)3, MA (GS)2 and DMA (GS) under different conditions. ...