Artemisinin-based combination therapies (ACTs) have, over the past decade, been adopted globally as first-line drugs for the treatment of Plasmodium falciparum malaria. These drugs have proven to be highly successful in treating malarial parasites resistant to the former first-line drugs chloroquine (CQ) and sulfadoxine/pyrimethamine (SP). Combined with expanded Anopheles vector control measure...

Abstract: Malaria is a potentially fatal parasitic disease brought on by five Plasmodium species, including falciparum, vivax, ovale, malariae, and knowlesi. The fast emergence of P. falciparum resistance to currently available treatments has increased health concerns in developing countries. growth emphasizes the need for novel, secure, cost-effective antimalarial drug that can treat malaria r...

Artemisinin-derived monomers and dimers inhibit human cytomegalovirus (CMV) replication in human foreskin fibroblasts (HFFs). The monomer artesunate (AS) inhibits CMV at micromolar concentrations, while dimers inhibit CMV replication at nanomolar concentrations, without increased toxicity in HFFs. We report on the variable anti-CMV activity of AS compared to the consistent and reproducible CMV ...

BACKGROUND Artemisinins, the most effective antimalarials available, are not recommended for falciparum malaria during the first trimester of pregnancy because of safety concerns. Therefore, quinine is used despite its poor effectiveness. Assessing artemisinin safety requires weighing the risks of malaria and its treatment. We aimed to assess the effect of first-trimester malaria and artemisini...

Artemisinin (ART) or Qinghaosu is a natural compound possessing superior anti-malarial activity. Although intensive studies have been done in the medicinal chemistry field to understand the structure-effect relationship, the biological actions of artemisinin are poorly understood and controversial. Due to the current lack of a genetic amiable model to address this question, and an accidental fi...

The biological actions of artemisinin (ART), an antimalarial drug derived from Artemisia annua, remain poorly understood and controversial. Besides potent antimalarial activity, some of artemisinin derivatives (together with artemisinin, hereafter referred to as ARTs), in particular dihydroartemisinin (DHA), are also associated with anticancer and other antiparasitic activities. In this study, ...

In 2019, a new virus called Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) gave rise to an unknown outbreak that spread in China’s Hubei province, triggering epidemic known as coronavirus-19 (COVID -19). Several studies have demonstrated the metabolic pathways of SARS-COV-2 angiotensin-converting enzyme receptors (ACE2). With this, others been considering approach with drugs bind ...

The mechanism of action of artemisinin antimalarials may be ascribed to C-centered radicals that alkylate biomolecules or to the peroxide moiety, which inhibits a specific, as yet undefined, target (4). It is also proposed that artemisinins kill the parasite through inhibition of hemozoin formation, thereby allowing buildup of toxic heme monomer (1, 2, 5). Artemisinin and dihydroartemisinin may...