In this paper we consider drug binding in the arterial wall following delivery by a drug-eluting stent. Whilst it is now generally accepted that a non-linear saturable reversible binding model is required to properly describe the binding process, the precise formof the bindingmodel varies between authors.Our particular interest in this manuscript is in assessing to what extent modelling specifi...

THE treatment of cancer by the local application of chemical substances has been practised since the time of Hippocrates. Moore, writing in the British Medical Journal of 1866, commented on the failure of occasional applications of caustic pastes in the treatment of cancer and suggested the necessity for a long continued stream of the medicinal agent flowing through the tumour. Modern chemother...

the marked shift in the patterns of drug use in iran, from opium smoking to injecting drug use, has led to serious health-related outcomes. this study was designed to explore characteristics of people who inject drugs (pwid) in tehran, iran. nine hundred and four pwid were recruited from treatment and harm reduction facilities, as well as drug user hangouts in public areas in tehran. participan...

BACKGROUND The intricacies of stent design, local pharmacology, tissue biology, and rheology preclude an intuitive understanding of drug distribution and deposition from drug-eluting stents (DES). METHODS AND RESULTS A coupled computational fluid dynamics and mass transfer model was applied to predict drug deposition for single and overlapping DES. Drug deposition appeared not only beneath re...

BACKGROUND Non-medical use of methylphenidate is increasing. Little is known about potential acute medical complications associated with recreational use of methylphenidate. STUDY AIM To identify medical problems associated with methylphenidate abuse. METHODS Retrospective case series of methylphenidate abuse cases presenting to an inner city emergency department. RESULTS We identified 14...

We determined the cardiovascular and neurohormonal responses to intracerebroventricular injection of leptin in conscious rabbits. Intracerebroventricular injection of leptin elicited dose-related increases in mean arterial pressure and renal sympathetic nerve activity while producing no consistent, significant increases in heart rate. Peak values of mean arterial pressure and renal sympathetic ...

Cocaine may cause stroke, intracranial hemorrhage, seizures, and neurobehavioral abnormalities in fetuses, newborns, and adults, and there could be developmental and/or species differences in mechanisms for these cocaine-induced cerebrovascular effects. To evaluate developmental differences in responses to cocaine, we compared the cerebrovascular and metabolic responses to a 2 mg/kg iv cocaine ...

BACKGROUND Endocarditis is a common complication in Staphylococcus aureus bacteremia (SAB). We compared risk factors, clinical manifestations, and outcome in a large, prospective cohort of patients with S. aureus endocarditis in injection drug users (IDUs) and in nonaddicts. METHODS Four hundred and thirty consecutive adult patients with SAB were prospectively followed up for 3 months. Defini...