arteriosclerosis

AIM To evaluate progression of arteriosclerosis using cardio-ankle vascular index(CAVI) and carotid duplex ultrasonography(DUS) in young and adolescent patients considered to be at risk of cardiovascular disease. METHODS We evaluated the progression of arteriosclerosis using CAVI and carotid DUS in 240 young and adolescent patients. Dyslipidemia(DL), hypertension(HT), and diabetes mellitus(DM...

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Addition of a renin-angiotensin-aldosterone system inhibitor to a calcium channel blocker ameliorates arterial stiffness

2015

Shunsuke Kiuchi Shinji Hisatake Muneyasu Kawasaki Osamu Hirashima Takayuki Kabuki Junichi Yamazaki Takanori Ikeda

BACKGROUND The aim of controlling hypertension is to protect against arteriosclerosis. Calcium channel blockers (CCBs) and renin-angiotensin-aldosterone system (RAAS) inhibitors have been reported to have antihypertensive effects, but their effect on the progression of arteriosclerosis is not fully understood. The cardio-ankle vascular index (CAVI) was developed to estimate arterial stiffness, ...

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Regression by ACE inhibition of arteriosclerotic changes induced by chronic blockade of NO synthesis in rats.

Journal: :American journal of physiology. Heart and circulatory physiology 2001

M Katoh K Egashira C Kataoka M Usui M Koyanagi S Kitamoto Y Ohmachi A Takeshita H Narita

We previously reported that chronic inhibition of nitric oxide (NO) synthesis with N(omega)-nitro-L-arginine methyl ester (L-NAME) induces vascular inflammation at week 1 and produces subsequent arteriosclerosis at week 4 and that cotreatment with an angiotensin-converting enzyme (ACE) inhibitor prevents such changes. In the present study, we tested the hypothesis that treatment with an ACE inh...

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