BACKGROUND Predicting acute renal failure in patients with severe sepsis is important, because patients may need renal replacement therapy (RRT). Neutrophil gelatinase-associated lipocalin (NGAL) has been evaluated for its ability to detect and predict acute kidney injury (AKI) in critically ill patients. This study aimed to assess the predictive value of plasma NGAL for acute renal failure in ...

Background: Detecting significant renal injury in an accurate and timely manner acute kidney (AKI) patients who are critically ill remains controversial. Serum creatinine (Cr) is important marker of function clinical practice, its limitations well known. Objectives: This study aimed to evaluate neutrophil gelatinase-associated lipocalin (NGAL) as a the early development AKI patients. Methods: p...

Background Acute kidney injury (AKI) occurs frequently after cardiac surgery using cardiopulmonary bypass (CPB). Conventional markers of kidney function like creatinine and potassium concentration are unreliable indicators during acute changes in kidney function and demonstrate injury late in the clinical course. Therefore, in the search of more sensitive biomarkers for monitoring AKI following...

Individuals with acute heart failure exacerbation often experience a deterioration in renal function. We sought to determine whether this deterioration is ischemic in nature and detectable by sensitive urine biomarkers neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1). We measured serial biomarker levels and evaluated the associations of these biomarkers wit...

The present study aimed to investigate the effect of exposure mosquito coil fumes (6 hr/day, 6 days/week, for 4 weeks) on biochemical and histological structure kidney in young adult male rats. Atomic analysis was estimated indicate main constituent elements coil. Results showed a non-significant change body weight gain somatic indices, except heart index that increased significantly both ages ...

BACKGROUND Urinary neutrophil gelatinase-associated lipocalin (U-NGAL) is an early predictor of acute kidney injury and adverse events in various diseases; however, in acute decompensated heart failure patients, its significance remains poorly understood. This study aimed to investigate the prognostic value of U-NGAL on the first day of admission for the occurrence of acute kidney injury and lo...

Acute renal failure secondary to ischemic injury remains a common problem, with limited and unsatisfactory therapeutic options. Neutrophil gelatinase-associated lipocalin (NGAL) was recently shown to be one of the maximally induced genes early in the postischemic kidney. In this study, the role of NGAL in ischemic renal injury was explored. Intravenous administration of purified recombinant NGA...

Delayed graft function (DGF) due to tubule cell injury frequently complicates deceased donor kidney transplants. We tested whether urinary neutrophil gelatinase-associated lipocalin (NGAL) and interleukin-18 (IL-18) represent early biomarkers for DGF (defined as dialysis requirement within the first week after transplantation). Urine samples collected on day 0 from recipients of living donor ki...

INTRODUCTION Neutrophil gelatinase-associated lipocalin (NGAL) has been identified as a biomarker of acute kidney injury (AKI) that could contribute to early diagnosis and effective management of AKI. The purpose of this study was to evaluate NGAL as a predictive marker of AKI in patients with clinically severe obesity (BMI >50) who underwent biliopancreatic diversion surgery. PATIENTS AND ME...