A thorough understanding of drug metabolism and disposition can aid in the assessment of efficacy and safety. However, analytical methods used in pharmacokinetics (PK) studies of protein therapeutics are usually based on ELISA, and therefore can provide a limited perspective on the quality of the drug in concentration measurements. Individual post-translational modifications (PTMs) of protein t...

Nitrofurazone is one of the antibacterial nitrofuran agents used topically for skin infections. The drug is effective on the majority of infectious microorganisms. Because of the importance of this drug in clinic, in this study various methods of synthesis of nitrofurazone were examined and the most appropriate method, applicable to pharmaceutical industry was chosen and optimized from the poin...

We have established a certification system for antibodies to be used in chromatin immunoprecipitation assays coupled to massive parallel sequencing (ChIP-seq). This certification comprises a standardized ChIP procedure and the attribution of a numerical quality control indicator (QCi) to biological replicate experiments. The QCi computation is based on a universally applicable quality assessmen...

Mobile healthcare social networks (MHSNs) have emerged as a promising next-generation healthcare system, which will significantly improve the quality of life. However, there are many security and privacy concerns before personal health information (PHI) is shared with other parities. To ensure patients' full control over their PHI, we propose a fine-grained and scalable data access control sche...

An attractive way to control attribute data from high quality processes is to wait till r ≥ 1 failures have occurred. The choice of r in such negative binomial charts is dictated by how much the failure rate is supposed to change during Outof-Control. However, these results have been derived for the case of homogeneous data. Especially in health care monitoring, (groups of) patients will often ...

Savvy consumers attribute a product’s market performance to its intrinsic quality as well as the seller’s marketing push. This paper studies how sellers should optimize their marketing decisions in response. The authors find that a seller can benefit from “demarketing” its product, meaning visibly toning down its marketing efforts. Demarketing lowers expected sales ex ante but improves product ...

In traditional access control models like mandatory access control (MAC), discretionary access control (DAC), and role-based access control (RBAC), authorization decisions are determined according to the identities of subjects and objects, which are authenticated by a system completely. Recent access control practices, such as digital rights management (DRM), trust management, and usage control...

In the present investigation we conducted three studies to examine how unconscious valence processing influences participants’ quality judgments in an attribute-framing task. In Studies 1 and 2 we observed how individuals who had depleted cognitive resources, through distraction (Study 2) and time constraint (Study 3), differed in their responses to an attribute-framing task. In Study 3 we subl...

Background: Quality assurance in the hematology laboratory is a must to ensure laboratory users of reliable test results with high degree of precision and accuracy. Even after so many advances in hematology laboratory practice, pre-analytical errors remain a challenge for practicing pathologists. This study was undertaken with an objective to ...