McKenna K, Koren G, Tetelbaum M, et al. Pregnancy outcome of women using atypical antipsychotic drugs: A prospective comparative study. J Clin Psychiatry 2005;66:444–9. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...

The author reviewed the relatively poor literature on the topic and its key clinical trial reports on perazine, a classical antipsychotic most frequently prescribed in Poland for psychoses, especially for schizophrenia. Based mainly on the Leucht and Hartung's metaanalysis as well as on other authors' trials with broader context of typical and atypical neuroleptics comparisons, it could be conc...

Mental illness constitutes the second-largest disease burden in the United States. Psychosis is one of the most common and severe mental illnesses. It is an extremely devastating condition characterised by delusions, hallucinations, distortion of thoughts and deteriorating social functioning experiences. Psychosis in all human societies has approximately same incidence of occurrence as in accor...

380 J Clin Psychiatry 58:9, September 1997 © Coyright 997 Phsicians Poraduate Pess, nc. ne pesonal opy ay be pinted social functioning, which far too many patients experience. The new atypical antipsychotics have attempted to put together the right blend of pharmacologic mechanisms and eliminate the misfits in order to compose an even better symphony than the one played by clozapine, so the new...

Aim: To review the relationship between the metabolic syndrome and atypical antipsychotics. Method: Selective literature review. Results: Atypical antipsychotics are effective in the treatment of psychotic disorders and other mental illness. Psychiatric patients have higher rate of physical disorders due to various causes, and metabolic disorders such as diabetes mellitus were described prior t...

AIMS AND METHOD To evaluate the effectiveness of the antipsychotic medication review service (AMRS) at the Maudsley Hospital. Patient notes were analysed from the AMRS and estimates of Global Assessment Scale (GAS) scores were made from entries in the notes. Data on hospital admissions before and during attendance at the AMRS were obtained from the trust-wide computerised patient administration...

Reports of diabetes, diabetic ketoacidosis, hyperglycemia, and dyslipidemias in patients treated with atypical antipsychotics have increased in recent years. This increase has led to growing concern about a possible link between these metabolic effects and atypical antipsychotic therapy. This review article provides an overview of the evidence for an association between glucose and lipid dysreg...

Olanzapine is an atypical antipsychotic which is efficacious in the treatment of schizophrenia. The adverse effect profile for olanzapine is benign except for higher rates of metabolic events. Orthostatic hypotension is less commonly reported with olanzapine as compared to first-generation and few atypical antipsychotics. We report a case where olanzapine, in a dose dependent fashion, caused tr...

The present study deals with the functional interaction of antipsychotic drugs and NMDA receptors. We show that both the conventional antipsychotic drug haloperidol and the atypical antipsychotic drug clozapine mediate gene expression via intracellular regulation of NMDA receptors, albeit to different extents. Data obtained in primary striatal culture demonstrate that the intraneuronal signal t...

Use of biodegradable polymers as drug carriers mainly depends on desired degradation mechanisms and mechanical properties. Schizophrenia requires medication for months to years. Presently, all the existing atypical preparations have to be given daily. Non-compliance is a major problem in these patients. Risperidone is an atypical antipsychotic and drug of choice for the treatment of