نتایج جستجو برای: autoimmune lymphoproliferative synd
تعداد نتایج: 67222 فیلتر نتایج به سال:
The p21 RAS subfamily of small GTPases, including KRAS, HRAS, and NRAS, regulates cell proliferation, cytoskeletal organization, and other signaling networks, and is the most frequent target of activating mutations in cancer. Activating germline mutations of KRAS and HRAS cause severe developmental abnormalities leading to Noonan, cardio-facial-cutaneous, and Costello syndrome, but activating g...
Cryoglobulinemic vasculitis (CV) is an immune-complex-mediated systemic vasculitis involving small-medium sized vessels. A causative role of hepatitis C virus (HCV) in over 4/5 patients has been definitely established on the basis of epidemiological, pathological, and laboratory studies. There is great geographical heterogeneity in the prevalence of CV as well as other HCV-related immuno-lympho...
In autoimmune polyglandular syndromes (APS), several organ-specific autoimmune diseases are clustered. Although APS type I is caused by loss of central tolerance, the etiology of APS type II (APS-II) is currently unknown. However, in several murine models, depletion of CD4(+) CD25(+) regulatory T cells (T(regs)) causes a syndrome resembling human APS-II with multiple endocrinopathies. Therefore...
Bénédicte Neven,1-3 *Aude Magerus-Chatinet,1,3 *Benoit Florkin,4 Delphine Gobert,1,3 Olivier Lambotte,5 Lien De Somer,6 Nina Lanzarotti,1 Marie-Claude Stolzenberg,1 Brigitte Bader-Meunier,1,2 Nathalie Aladjidi,7 Christophe Chantrain,8 Yves Bertrand,9 Eric Jeziorski,10 Guy Leverger,11 Gérard Michel,12 Felipe Suarez,13 Eric Oksenhendler,14 Olivier Hermine,3,13 Stéphane Blanche,2 Capucine Picard,2...
In a review published in 1983, an attempt was made to highlight the rheumatological aspects of diseases generally regarded as haematological in origin.' Since then, a variety of reports have served to strengthen the links between these two areas of medicine. In this review, we consider these more recent reports and focus on patient presentation, advances in treatment, and knowledge of underlyin...
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