Background: Autoantibodies targeting a muscle-specific autoantigen, four-and-a-half-LIM-domain 1 (FHL1), have been previously identified in patients with idiopathic inflammatory myopathies (IIM) (1). Objectives: The aim of this project was to determine the prevalence and associations anti-FHL antibody South Australian histologically-confirmed IIM an autoimmune disease control (systemic sclerosi...

To describe the clinical manifestations, treatments, prognosis, and prevalence of autoimmune diseases (ADs) in human immunodeficiency virus (HIV)-infected patients.All HIV-infected patients managed in the Infectious Diseases Department of the Lyon University Hospitals, France, between January 2003 and December 2013 and presenting an AD were retrospectively included.Thirty-six ADs were found amo...

IMPORTANCE OF THE FIELD The main subtypes of inflammatory myopathies include dermatomyositis (DM), polymyositis (PM), necrotising myopathy (NM) and sporadic inclusion body myositis (sIBM). Recent observations have helped us to understand better the unique pathomechanisms of each subset. Advances in the pathogenesis of these disorders have led to a more precise diagnosis and specific therapeutic...

3-n-Butylphthalide (NBP) protects the mitochondria and reduces apoptosis in multiple disease models. However, it remains to be determined whether NBP can protect muscle cells from oxidative stress, lipid peroxidation and apoptosis in myositis. In the present study, a myosin immunization protocol was applied to induce experimental autoimmune myositis (EAM) in guinea pigs. After 4 weeks, a low- o...

Idiopathic inflammatory myopathy is a chronic inflammatory muscle disease characterized by mononuclear cell infiltration in the skeletal muscle. The infiltrated inflammatory cells express various cytokines and cytotoxic molecules. Chemokines are thought to contribute to the inflammatory cell migration into the muscle. We induced experimental autoimmune myositis (EAM) in SJL/J mice by immunizati...

PURPOSE OF REVIEW This article reviews the advances that have been made in our understanding of the genetics of the idiopathic inflammatory myopathies (IIM) in the past 2 years, with a particular focus on polymyositis, dermatomyositis and inclusion body myositis. RECENT FINDINGS Two large human leukocyte antigen (HLA) imputation studies have confirmed a strong association with the 8.1 ancestr...

AIMS To investigate the association between scleritis and myositis. METHODS Retrospective, non-comparative case series. Records and ultrasonograms were examined of 132 patients, with a diagnosis of episcleritis or scleritis, who attended the ophthalmology department at Leiden University Medical Center between 1997 and 2000. 103 were eligible for comprehensive examination. Medical records were...

Abstract Although immune checkpoint inhibitors (ICIs) have improved systemic cancer care, in rare cases, patients develop neuromuscular related adverse events (irAEs), which carry high morbidity and mortality. This case study describes an 85-year-old male who developed the triad of myositis, myasthenic crisis, myocarditis association with ICI treatment for metastatic urothelial carcinoma (T3N0M...

BACKGROUND Systemic sclerosis (SSc) is a rare and devastating disease affecting skin and internal organs. Familial aggregation of SSc and co-aggregation with other autoimmune diseases is rarely reported. METHODS We identified 23,658,577 beneficiaries registered with the National Health Insurance database in 2010, 1891 of whom had SSc. We identified 21,009,551 parent-child relationships and 17...

fibrodysplasia ossificans progressiva (fop) is a rare hereditary connective tissue disease characterized by the progressive ectopic ossification of ligaments, tendons, and facial and skeletal muscles throughout life. symptoms begin in childhood as localized soft tissue swellings. immobility and articular dysfunction appear with involvement of the spine and proximal extremities. the temporomandi...