Transthyretin familial amyloid polyneuropathy (TTR-FAP) is a rare, progressive, life-threatening, hereditary disorder caused by mutations in the transthyretin gene and characterized by extracellular deposition of transthyretin-derived amyloid fibrils in peripheral and autonomic nerves, heart, and other organs. TTR-FAP is frequently diagnosed late because the disease is difficult to recognize du...

This study used a small wearable heart rate sensor to monitor the daily autonomic function of 600 subjects from across all age groups over a prolonged period of time. The results indicated that the LF/HF ratio (Heart Rate Variability, LF: frequencies between 0.04 Hz 0.15 Hz, HF: frequencies between 0.15 Hz 0.4 Hz) an indicator of balance in the autonomic nervous system, tended to peak for subje...

An abdominal operation combines a somatic abdominal wall wound with a second autonomic wound to the peritoneal cavity and viscera and little attention has been paid the autonomic/peritoneal wound that communicates directly to the brain by the vagus nerve. Moreover, vagal input originating from the peritoneum modulates and regulates postoperative recovery. Consequently, blockade of the afferent ...

Botulism is an acute neurologic disorder that causes potentially life-threatening neuroparalysis resulting in weakness and laccid paralysis. In addition to the autonomic nervous system, botulism may involve only the cranial nerves, thus posing special diagnostic problems. Almost all cranial nerves are not easily testable. The anatomical and physiological characteristics of the spinal accessory ...

Neuropathic pain is an important problem because of its complex natural history, multiple possible etiologies, and poor response to standard physical therapy modalities. Disorders of the peripheral nerve system (PNS) are heterogeneous and may involve motor fibers, sensory fibers, small myelinated and unmyelinated fibers and autonomic nerve fibers, with variable anatomical distribution (single n...

A 9-year-old female developed bilateral leg weakness on the same day she received an influenza vaccination. Her condition had gradually worsened during the 5 months prior to her presentation. She had no family history of hereditary disease. Physical examination revealed muscle atrophy without fasciculation in all four limbs. Muscle power in the proximal and distal limbs was 3 of 5, and the deep...

Neuropathic pain is an important problem because of its complex natural history, multiple possible etiologies, and poor response to standard physical therapy modalities. Disorders of the peripheral nerve system (PNS) are heterogeneous and may involve motor fibers, sensory fibers, small myelinated and unmyelinated fibers and autonomic nerve fibers, with variable anatomical distribution (single n...

a b c Type 2 Diabetes mellitus cardiac autonomic neuropathy autonomic function tests Original Article AIM: Prevalence of Diabetes is increasing globally and India is no exception One of the most important complication of diabetes is Cardiac Autonomic Neuropathy (CAN)which results from damage to the autonomic nerve fibers that innervate heart and blood vessels The integrity of the autonomic syst...

The vagus nerve (VN) is the longest nerve of the organism and a major component of the parasympathetic nervous system which constitutes the autonomic nervous system (ANS), with the sympathetic nervous system. There is classically an equilibrium between the sympathetic and parasympathetic nervous systems which is responsible for the maintenance of homeostasis. An imbalance of the ANS is observed...