introduction: alzheimer’s disease (ad) is an age-related neurodegenerative disease, which impairs memory and cognitive function. walnuts are a dietary source of polyphenols, antioxidants and other compounds with health beneficial effects. these characteristic of walnuts make them perfect candidates for evaluation of their possible effects on neurodegenerative diseases. therefore the present stu...

abstract: introduction: nitric oxide (no) is a retrograde messenger in hippocampal synaptic plasticity which involves in learning and memory processes. previous studies revealed that hippocampal pyramidal cells contain no synthase (nos) enzyme which produce no and could be a promising target to evaluate the role of no in brain cognitive functions. so in this study, using nos inhibitor (l-name),...

The present study examined the influence of dexefaroxan, a potent and selective alpha(2)-adrenoceptor antagonist, on cognitive performance in rodents. In young adult rats, dexefaroxan reversed the deficits induced by UK 14304 [5-bromo-N-(4,5-dihydro-1-H-imidazol-2-yl)-6-quinoxalinamine], scopolamine, and diazepam in a passive avoidance task. In this test, dexefaroxan also attenuated the spontan...

In both humans and laboratory animals, the reports of cognitive effects following acute amphetamine (Amph) administration are mixed and depend, for example, on the timing of administration (e.g. before or after task acquisition) and/or on the memory model used. Besides its cognitive effects, Amph produces other important behavioural effects, including alterations in anxiety and general activity...

introduction: learning and memory deficits in some diseases are new subjects of research. bupropion, as dopamine and noradrenaline reuptake inhibitor and an antidepressant agent, has been previously shown to affect learning and memory processes. this study was designed to test the effect of intra-hippocompal bupropion injection on active avoidance learning task in rats. methods: adult male wist...

OBJECTIVE To investigate the neuropsychopharmacological effect of a polyherbal formulation (PHF) on the learning and memory processes in rats. MATERIALS AND METHODS PHF contains Withania somnifera (Ashwagandha), Nardostachys jatamansi (Jatamansi), Rauwolfia serpentina (Sarpagandha), Evolvulus alsinoides (Shankhpushpi), Asparagus racemosus (Shatavari), Emblica officinalis (Amalki), Mucuna prur...

Our aim was to investigate the effects of acute harmane administration upon learning and memory performance of rats using the three-panel runway paradigm and passive avoidance test. Male rats received harmane (2.5, 5, and 7.5mg/kg, i.p.) or saline 30 min. before each session of experiments. In the three panel runway paradigm, harmane did not affect the number of errors and latency in reference ...

Although much has been learned about the role of the amygdala in Pavlovian fear conditioning, relatively little is known about the signaling pathway involved in the acquisition of an active avoidance reaction. The aim of this study is to investigate the potentiating effects of the NO-guanylate cyclase activator YC-1 on learning and memory of shuttle avoidance test in rats. YC-1 enhanced the ind...

Goldfish received either 20 or 50 active avoidance training trials followed by puromycin (or no-treatment) and 10 retraining trials either 1 or 7 days following training. While 50 trials resulted in significantly more training avoidances than 20 trials, the groups which received puromycin showed equivalent retention deficits on Day 7. A within-group comparison of fish whose training performance...

Four experiments were conducted to examine social and emotional memory in the R6/2 transgenic mouse model of Huntington's disease. First, R6/2 mice were tested in a social transmission of food preference task where they had to acquire a preference for a flavoured food (acquisition) and subsequently to learn a preference for a different flavour (shifted reinforcement). R6/2 mice performed well i...