Histologic assessment is the gold standard technique for the identification of metastatic involvement of lymph nodes in malignant disease, but can only be performed ex vivo and often results in the unnecessary excision of healthy lymph nodes, leading to complications such as lymphedema. Optical coherence tomography (OCT) is a high-resolution, near-IR imaging modality capable of visualizing micr...

BACKGROUND The significance of micrometastatic disease in the sentinel lymph nodes (SLN) of patients with invasive breast cancer has been questioned. The objective of our study was to review the impact of micrometastatic carcinoma detected by SLN biopsy. STUDY DESIGN Between January 1997 and May 2004, 2,408 patients with invasive breast cancer and an SLN with micrometastatic (N0[i+], N1mi) or...

Non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL) represent a heterogeneous group of malignant lymphoid tumors, which have distinct histological and/or biological characteristics with preferential nodal involvement. However, none of the previous studies have assessed the prevalence of common NHL and HL subtypes at each nodal site of involvement. The aim of our study was to determine the prev...

BACKGROUND A few retrospective studies have indicated that neoadjuvant chemotherapy (NAC) in breast cancer may change biomarker profiles of the primary tumor. Little is known about the status of HER-2 gene of the synchronous nodal metastases when that of the residual tumor undergoes negative conversion in a neoadjuvant setting. CASE PRESENTATION We describe a female patient with left breast c...

In the era of effective systemic therapy, the decision on whether or not to recommend post-operative adjuvant radiotherapy for intermediate risk breast cancer remains a point of discussion in many multidisciplinary tumour board meetings. Variations in advice regarding post-mastectomy radiotherapy have been demonstrated within the context of guideline-based practice [1]. A recent survey of nodal...

INTRODUCTION Controversy persists concerning the role of pelvic lymph node dissection (PLND) in patients with clinically localized prostate cancer undergoing radical prostatectomy. The aim of this review is to critically evaluate the current status on PLND in prostate cancer. METHODS A review of the literature was performed concerning radical prostatectomy and PLND with respect to oncological...

Abstract Objectives We compared the clinicopathologic features, clinical management, and outcomes of human epidermal growth factor receptor 2 (HER2)–expressing nonexpressing microinvasive breast carcinomas (MiBC) to explore significance HER2 in MiBC. Methods Clinicopathologic follow-up information cases with final diagnosis MiBC known status between 2007 2019 were analyzed. Results Nineteen (41...