This study aimed to analyze the impact of etiologic heterogeneity and operation age on prognosis of infants with biliary atresia (BA) who received Kasai operation prior to 60 days of age.From 2004 to 2010, 158 infants received Kasai operation before turning 60 days old. According to Davenport 2012 classifications, 4 groups of BA were defined: cystic BA, syndrome BA, and associated malformation,...

Cholesterol 7α-hydroxylase (CYP7A1) is the initiating and rate-limiting enzyme in the neutral pathway that converts cholesterol to primary bile acids (BA). CYP7A1-deficient (Cyp7a1(-/-)) mice have a depleted BA pool, diminished intestinal cholesterol absorption, accelerated fecal sterol loss, and increased intestinal cholesterol synthesis. To determine the molecular and physiological effects of...

We investigated the morphology of the N1-P2 auditory evoked potential (AEP) to changes in amplitude rise time (ART) and rate of formant transition (RFT) of consonant-vowel pairs (CVs) in 4-6-year olds and adults. In the AEP session, individuals listened passively to the CVs /ba/, /wa/, and a /ba/ with a superimposed slower-rising /wa/ envelope (/ba/wa). In the behavioral session, individuals li...

Betulinic acid (BA), a pentacyclic triterpene, is an experimental cytotoxic agent for malignant melanoma. Here, we show that BA triggers apoptosis in five human glioma cell lines. BA-induced apoptosis requires new protein, but not RNA, synthesis, is independent of p53, and results in p21 protein accumulation in the absence of a cell cycle arrest. BA-induced apoptosis involves the activation of ...

Although the role of the amygdala in acquisition of conditioned fear is well established, there is debate concerning the intra-amygdala circuits involved. The lateral nucleus of the amygdala (LA) is thought to be an essential site of plasticity in fear conditioning. The LA has both direct and indirect [via the basal nuclei; basal amygdala (BA)] projections to the central nucleus (Ce) of the amy...

Barium (Ba) incorporated in the calcite of many foraminiferal species is proportional to the concentration of Ba in seawater. Since the open ocean concentration of Ba closely follows seawater alkalinity, foraminiferal Ba /Ca can be used to reconstruct the latter. Alternatively, Ba /Ca from foraminiferal shells can also be used to reconstruct salinity in coastal settings in which seawater Ba con...

The standard-of-care treatment for biliary atresia (BA) is surgical restoration of bile flow by Kasai portoenterostomy. We aimed to study serum interleukin- (IL-) 12p40, a natural antagonist for the proinflammatory IL-12p70, and its relation to surgical outcomes of BA. The study included 75 infants with neonatal cholestasis: BA group (n = 25), non-BA cholestasis group (n = 30), and neglected BA...

Butyric acid (BA), one of the short chain fatty acids (SCFAs), has positive actions on the metabolism, inflammation, etc. However, whether it influences the reproductive physiology and if so the detail mechanism involved has not yet been determined. In this study, the porcine granulosa cells (PGCs) were treated with gradient concentrations of BA. After 24h culture, 0.05mM BA significantly stimu...

Uygun ekolojik ko?ullar? ve binlerce y?ll?k kültürel birikimi, ba?c?l???n Tekirda?’da önemli ekonomik kaynaklardan biri olmas?n? sa?lam??t?r. Trakya dâhilinde Tekirda?, il de ?arköy Süleymanpa?a ilçeleri ba? alan? üzüm üretiminde önde gelir. Sofral?k ?arapl?k üretiminin yap?ld??? sahada, alanlar?, toplam alanlar?n?n %66,3’ünü olu?turur. Özellikle ?arköy, üretimi baz? büyük i?letmelerin yan? s?r...