Many autoimmune diseases feature functional or genetic defects that can alter NF-kB function. In an animal model of type 1 diabetes and Sjogren’s syndrome, a defective proteasome prevents NK-kB-induced gene transcription by precluding cleavage of IkBa from NF-kB in the cytoplasm. Polymorphisms in such NK-kB related genes as SUMO4, NOD2, IKBL, IRF-5, TNFAIP3, TNF, TNFR1, TNFR2, IL-10 and DLG-5 h...

Background: Bacillus Calmette ET Guerin (BCG) vaccine, compulsory in endemic areas, remains the only available vaccine for prevention of Tuberculosis (TB) despite its modest protective value. Complications may arise in healthy/ immunocompromized hosts. Methods: Children presenting with BCG vaccine related complications in the form of local/distant complications were enrolled from 2007-2010 at C...

BCG (Bacillus Calmette-Guérin) immunotherapy is a method which an emerging form of cancer treatment. attaches to the bladder wall and stimulates immune response destroy cells. Complications therapy are due reactivated infection or hypersensitivity reaction thus may be treated with antimycobacterial agents, corticosteroids, both. instillations should also stopped if complications occur during tr...