Here, we report the characterization of 122 Pseudomonas aeruginosa clinical isolates from three distinct geographical locations: Dartmouth Hitchcock Medical Center in New Hampshire, USA, the Charles T. Campbell Eye Microbiology Lab at the University of Pittsburgh Medical Center, USA, and the Aravind Eye Hospital in Madurai, India. We identified and located clustered regularly interspaced short ...

Studies of susceptibility to bacteriophage have shown that polysaccharides associated with somatic bacterial antigens may inhibit the lytic action of bacteriophages upon susceptible homologous organisms. Levine and Frisch (1933 a,b) demonstrated this inhibitory effect with extracts from certain Salmonella and Shigella cultures. Burnet (1934) confirmed these findings; and Gough and Burnet (1934)...

An experiment was conducted to evaluate the effects of bacteriophage supplementation on egg performance, egg quality, excreta microflora, and moisture content in laying hens. A total of 288 Hy-line brown commercial laying hens (36-wk-old) were randomly allotted to 4 treatments in this 6-wk trial and dietary treatments included: i) CON, basal diet; ii) T1, CON+0.020% bacteriophage; iii) T2, CON+...

There are at the present time two schools of thought with reference to the nature of bacteriophage. One group, championed chiefly by d'Herelle and Burner, considers phage to consist of living "corpuscles," while the other group views the lyric principle as partaking of all the major characteristics of an enzyme. A study of the kinetics of the bacterium-bacteriophage reaction by Krueger and Nort...

There are at the present time two schools of thought with reference to the nature of bacteriophage. One group, championed chiefly by d'Herelle and Burner, considers phage to consist of living "corpuscles," while the other group views the lyric principle as partaking of all the major characteristics of an enzyme. A study of the kinetics of the bacterium-bacteriophage reaction by Krueger and Nort...

Many pathogenic bacteria have bacteriophage and other mobile genetic elements whose activity during human infections has not been evaluated. We investigated the gene expression patterns in human subjects with invasive Methicillin Resistant Staphylococcus aureus (MRSA) infections to determine the gene expression of bacteriophage and other mobile genetic elements. We developed an ex vivo techniqu...

In previous studies (Labaw, Mosley, and Wyckoff, 1950a, b) from this laboratory we have shown that large yields of bacteriophage can be obtained from cultures of Escherichia coli which have been exposed to enough ultraviolet radiation to prevent their subsequent growth to form observable colonies when spread on fresh nutrient agar. In this work it was found that though the phosphorus metabolism...

The inactivation mechanism of virus and bacteria by atmospheric discharge plasma has been studied actively. However, predominant factors in the inactivation are not clear at all. Because the atmospheric discharge plasma includes a lot of possible inactivation factors such as active oxygen species, ozone and ultraviolet rays, it is difficult to analyze each effect separately. In this study, bact...