drug therapeutic and toxic effects. The change of the compatibility of traditional Chinese medicines may lead directly to the change of the metabolism of drug effectiveness in human body. Therefore, the investigation of the metabolism of compound Chinese recipes by modern analytical techniques may play important roles in explanation of the functional mechanisms and compatibility principles of c...

Glaesserella parasuis (G. parasuis) can cause peritonitis in piglets. However, the pathogenesis of remains unclear. Baicalin has been shown to possess anti-inflammatory and anti-oxidant functions. The aim this study was investigate role PANX-1/P2X7 axis P2Y6 signaling pathway induced by G. effect baicain on activation triggered parasuis. A serovar 5 isolate SH0165 strain obtained from lungs com...

A specific ultra-performance liquid chromatography–mass spectrometry (UPLC–MS) method was developed for the simultaneous determination of puerarin, daidzein, baicalin, wogonoside and liquiritin in rat plasma. Chromatographic separation was performed on a C18 column packed with 1.7 m particles by a linear gradient elution. The analytes and carbamazepine (internal standard, I.S.) were monitored i...

Aims: The present work aimed to evaluate the anti-amoebic, antibacterial, and anti-inflammatory potential of three natural polyketides from Phomopsis sp. CAM212.
 Study Design: Clinical isolates E.histolytica, E.coli ATCC25922 strain, primary peritoneal mouse macrophages were used.
 Places Duration Study: Laboratory Pharmacology Toxicology, Medical Microbiology, Faculty Science, Unive...

− Systemic lupus erythematosus (SLE) is a systemic inflammatory autoimmune disease characterized by abnormalities in T cell immunoregulation and hyperreactivity of B cells, leading to autoantibody production and multiorgan injuries. We investigated the effect of baicalin on aberrant immunoregulation in pristane-induced lupus mice. Mice received i.p. a single injection of 0.5 ml of pristane or P...

Extracts from raw materials from different plant parts, tissue-cultured plants, and callus cultures of Oroxylum indicum were analyzed for in vitro antioxidant activities determined by DPPH radical scavenging assay and evaluated for phytochemical profiles by TLC and LC-MS methods. The results were analyzed by principal component analysis (PCA) to evaluate the similarity. Stalk, pedicel, flower, ...

The active compounds in the roots of Scutellaria baicalensis Georgi, a traditional Chinese medicinal plant, are mainly flavonoids which have anti-inflammatory, antitumour, and anti-HIV activity, respectively. The increasing annual average temperature has rendered the S. baicalensis plants grown in some ancient producing regions no longer suitable for their medicinal usage. Hydrogen peroxide pla...

This study was aimed to investigate the effects of baicalin (BA), a major flavonoid constituent found in the herb Baikal skullcap, on dendritic cells (DCs). DCs were generated by culturing murine bone marrow (BM) cells for 6 days with granulocyte-macrophage colony-stimulating factor and interleukin (IL)-4, and lipopolysaccharide (LPS) was added on day 5 to stimulate DCs maturation. The expressi...