iron overload is known to occur in the west european and american population due to the consumption of iron-rich diets. on the other hand, genetic disorders leading to iron overload are also known. iron overload leads to increased peroxidation and disruptive disintegration of lipid-rich membranes, and predisposes humans for an enhanced risk of cancer induction. in experimental animals iron over...

objective: it has been shown that berberine, a major component of berberis vulgaris extract, modulates the activity of several neurotransmitter systems including dopamine (da) and n-methyl-d-aspartate (nmda) contributing to rewarding and reinforcing effects of morphine. drug craving and relapsing even after a long time of abstinence therapy are the most important problems of addiction. in the p...

d-galactose induces pancreatic disorder along with aging mouse model. vitex agnus-castus (vac) has potential pancreatic protective effect. hence, this study was designed to evaluate the hypoglycemic and pancreas protective effects of vac hydroalcoholic extract in d-galactose-induced aging female mice. in the present experimental study, 72 adult female naval medical research institute (nmri) mic...

in the present study, interactions of dopamine receptor agonists and antagonists with water swimming stress (wss) on naloxone-induced jumping in morphine-dependent mice were examined. mice were rendered dependent as described in the methods section. the opioid receptor antagonist, naloxone (1 mg/kg), was injected to elicit jumping (as a withdrawal sign). the first group exposed to wss in the pr...

lead is an ubiquitous environmental toxin that induces a broad range of physiological biochemical, and behavioral dysfunctions. in this study, we examined the pathologic effects of lead acetate in nmri mouse ovarian tissue and the protective role of antioxidant l-cysteine, against the induced damage. we used lead acetate at a dose of 10 mg/kg, and l-cysteine at a dose of 200 mg/kg. both drugs w...

organotypic spinal cord slices from neonatal mammals could be a powerful model for evaluation of cell survival but also cell death mechanisms. the aim of this study was to establish an in vitro model for investigating cell survival and mechanism involved in cell death in neonatal spinal cord slices. the spinal cord was sliced and incubated into culture medium. the mtt assay was carried out to a...

three subspecies of mus musculus have been recognized in iran so far. the house mouse (genus0t 0t2tmus2t, species0t 0t2tmus musculus2t) are recognized for their highly conserved morphology and chromosomal structure, but some chromosomal characters offer accurate taxonomic markers in this species that has been shown any unambiguous diagnostic morphological traits. among the chromosomal character...

objective: to determine bilateral effects of unilateral iatrogenic vas deferens trauma (uit) on epididymal sperm characteristics and in vitro fertilizing capacity in an experimental mouse model. methods: experiments were performed on three equal groups each comprising six adult male mice. following anaesthesia, uit was induced by clamping left vas deferens with a mosquito clamp in fully locked ...

this study was aimed to assess the protective effects of cornus mas fruit extract (cmfe) and vitamin e (vit e) on sperm quality parameters in the methotrexate (mtx)-treated mice. forty-eight young adult male mice (8-12 weeks) were randomly divided into six groups including control and test groups. the control group received normal saline orally , and the test groups were treated mtx (20 mg kg-1...