نتایج جستجو برای: basic drugs
تعداد نتایج: 490930 فیلتر نتایج به سال:
The fluorescence of 1-anilinonaphthalene-8-sulfonate (ANS) in the presence of human liver microsomes (HLMs) is altered by drugs that bind nonspecifically to the lipid bilayer. The present study characterized the relationship between the nonspecific binding (NSB) of drugs to HLMs as measured by equilibrium dialysis and the magnitude of the change in baseline ANS fluorescence. Fraction unbound in...
Background: Cardiovascular disease is one of the chronic diseases with an increasing prevalence from year to year. The results Indonesia's basic health research (RISKESDAS 2018) showed that it was experienced by 2.9% population. Ensuring continuity drug availability very important in pharmacy services for this patient group. history use considered planning dan procurement products. Objective: T...
asthma affects an estimated 300 million people worldwide. poor compliance with the prescribed medication leads to increased mortality and morbidity. various determinants of compliance have been described. the purpose of this study was to determine factors that can influence patients' compliance with prescribed metered dose inhaler drugs. 179 patients with diagnosis of asthma were selected from ...
We describe a capillary gas-chromatographic method for detection and quantification of basic and neutral drugs in the plasma of patients thought to be poisoned after dangerous overdose. Without further derivatization, the drugs are extracted from 1 mL of plasma, at basic pH, into diethyl ether. The extracts are injected onto two fused-silica capillary columns of different polarity (Ultra 1 and ...
Academia and small business research units are poised to play an increasing role in drug discovery, with drug repurposing as one of the major areas of activity. Here we summarize project status for a number of drugs or classes of drugs: raltegravir, cyclobenzaprine, benzbromarone, mometasone furoate, astemizole, R-naproxen, ketorolac, tolfenamic acid, phenothiazines, methylergonovine maleate an...
Background and Aim: The analysis of patients’ safety clinical indicators is considered as one of the safety improvement instruments. Therefore, the present study is aimed to analyze the indices of safety clinical services in selected hospitals of Tehran University of Medical Sciences (TUMS). Materials and Methods: The present descriptive-analytical study was conducted in 11 TUMS hospitals in...
Lysosomotropic Properties of Weakly Basic Anticancer Agents Promote Cancer Cell Selectivity In Vitro
Drug distribution in cells is a fundamentally important, yet often overlooked, variable in drug efficacy. Many weakly basic anticancer agents accumulate extensively in the acidic lysosomes of normal cells through ion trapping. Lysosomal trapping reduces the activity of anticancer drugs, since anticancer drug targets are often localized in the cell cytosol or nucleus. Some cancer cells have defe...
background: poisoning is considered an important public health issue. considering the high prevalence of poisonings and the diversity of their ensuing symptoms, this study aimed to investigate the epidemiology of the clinical symptoms of poisoning in children admitted to shahid madani and ta'min ejtema'i hospitals of khorramabad in 2011. methods: in this cross-sectional study, the dat...
background: poisoning is a serious health problem in the world. in the intentional type, the person may attempt suicide by self-poisoning or may be poisoned by others in a criminal act. the present study was designed to investigate the causes and the frequency of poisoning cases referring to loqman hospital, tehran, iran, during summer 2010. methods: in this descriptive-analytical study, age, g...
conclusions findings reveal a significant degree of prescription errors, emphasizing the need for stringent surveillance. results a total of 227 case notes were reviewed, 129 (56.8%) of which belonged to male patients. no medication was prescribed for 13 patients, whereas 697 drug prescriptions (excluding intravenous fluids) were given for 214 patients, equaling 3.25 drugs/patient; antibiotics ...
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